Chlorpromazine

  • Chlorpromazine is used to treat a number of unrelated problems.
  • Do not drink alcohol while you are taking chlorpromazine.
  • The most common side-effects are drowsiness, dizziness, blurred vision and dry mouth.
  • Chlorpromazine may cause your skin to become more sensitive to sunlight. Protect your skin and do not use sunbeds.

About chlorpromazine

Type of medicineAntipsychotic
Used forAgitation and restlessness
Sickness in advanced diseases (palliative care)
Schizophrenia
Persistent hiccups
Also calledLargactil®
Available asTablets, oral solution, and injection

Chlorpromazine is used to treat a number of unrelated problems. It is used to relieve the symptoms of schizophrenia and some other mental health problems. Such symptoms include hearing, seeing or sensing things that are not real, having mistaken beliefs and unusual suspiciousness. It is also used to treat moments of sudden dangerous behaviour or agitation, and is useful in the treatment of anxiety for short periods of time. Chlorpromazine can also be used in in autism in children, for sickness associated with advanced or terminal illnesses, and to treat persistent hiccups.

Chlorpromazine is thought to work by blocking the action of a chemical called dopamine which acts on the nervous system in the brain.

Before taking chlorpromazine

Before taking chlorpromazine make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have heart or breathing problems.
  • If you have liver problems or an underactive thyroid.
  • If you have kidney or prostate problems.
  • If you have a blood disorder or have ever had jaundice.
  • If you have Parkinson's disease.
  • If you have epilepsy.
  • If you have diabetes.
  • If you are feeling depressed.
  • If you have glaucoma.
  • If you have had a stroke or TIA (sometimes called a 'mini stroke').
  • If you have myasthenia gravis (a condition that causes muscle weakness).
  • If you have phaeochromocytoma (a growth on the adrenal gland).
  • If you have bone marrow depression (a reduced immune system response).
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.

How to take chlorpromazine

  • Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack.
  • Take chlorpromazine exactly as your doctor has told you.
  • You may need to take chlorpromazine for several weeks before you feel the full effect.
  • Try to take chlorpromazine at the same times each day to avoid missing any doses.
  • If you do forget to take a dose do not worry, just take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

  • Chlorpromazine may cause drowsiness. Do not drink alcohol while you are taking chlorpromazine as it could increase these feelings of drowsiness.
  • Chlorpromazine may cause your skin to become more sensitive to sunlight than normal. Protect your skin from sunlight even on bright but cloudy days. Do not use sunbeds.
  • Keep your regular appointments with your doctor so your progress can be monitored. Your doctor may want to review this treatment regularly.
  • If you have diabetes check your blood glucose levels regularly as chlorpromazine can affect the levels of sugar in your blood.
  • Smoking may affect the amount of chlorpromazine in your body. Let your doctor know if you start or stop smoking while taking chlorpromazine.
  • If you buy any medicines, check with a pharmacist that they are safe to take with chlorpromazine.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking chlorpromazine.
  • Stopping treatment with chlorpromazine suddenly may cause your symptoms to return, so your doctor will probably want you to reduce your dose gradually if this is necessary.

Can chlorpromazine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
Drowsiness, sleepinessIf this happens do not drive or use tools or machines. Do not drink alcohol
Dizziness, or light-headedness especially when getting up from a standing or sitting positionGetting up slowly should help. If you begin to feel dizzy, lie down so that you do not faint, then sit for a few minutes before standing. If this continues, let your doctor know
Dry mouthTry chewing sugar-free gum or sweets. If this becomes troublesome, speak with your pharmacist or doctor
ConstipationTry to eat a well balanced diet containing plenty of fibre and drink 6-8 glasses of water each day. If constipation continues to be a problem speak with your pharmacist or doctor
Blurred visionMake sure that you can see properly before starting any task that would be dangerous if your vision is not clear
Over-heating in hot weather and not being able to get warm in cold weatherDo your best to keep cool in hot weather and wrap up warmly in cold weather. Let your doctor know about this
HeadacheAsk your pharmacist to recommend a suitable painkiller. If the headache continues, let your doctor know
Shakiness, abnormal movements of the face or body, restlessness, uncontrollable movements of the tongue, face or jawIf you experience any of these, see your doctor as soon as possible
Mood changes, trouble sleeping, blocked nose, difficulty passing urineIf any of these become troublesome, speak with your doctor

Important: If you experience 'flu like' symptoms such as muscle stiffness, a high temperature, a pale complexion, sweating, and a fast heart beat, you must contact your doctor immediately or go to your local accident and emergency department without delay.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store chlorpromazine

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2011DocID: 3496DocRef: dils2789Last Reviewed: 16 Jun 2011Version: 22
For the planned review period see the Data Creation and Quality Control Process.
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