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Brimonidine and timolol eye drops

  • Do not instil more than one drop - using several drops does not improve glaucoma and increases the risk of side effects.
  • Eye drops can be used for 4 weeks once the bottle has been opened. After this time use a new bottle.

About brimonidine and timolol eye drops

Type of medicineAlpha-agonist and beta-blocker
Used forGlaucoma
Raised pressure in the eye
Also calledCombigan®
Available asEye drops

Brimonidine and timolol eye drops work by stimulating chemical receptors found on blood vessels in the eye. This results in less fluid entering the eye which keeps the pressure in the eye low.

Before using brimonidine and timolol eye drops

Before using brimonidine and timolol eye drops make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you are taking antidepressant medication or if you suffer from depression.
  • If you suffer from asthma or have ever suffered from any other breathing problems.
  • If you have heart or heart rhythm problems.
  • If you have circulation problems (such as Raynaud's disease).
  • If you suffer from postural hypotension (dizziness when sitting up or standing quickly).
  • If you have liver or kidney problems.
  • If you have phaeochromocytoma (a growth on the adrenal glands).
  • If you have diabetes.
  • If you have an overactive thyroid.
  • If you have ever had an allergic reaction.
  • If you are taking other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to use brimonidine and timolol eye drops

  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • The usual dose is one drop twice a day (12 hours apart) into the affected eye(s).

How to use these eye drops:

  1. Wash your hands well before use.
  2. Remove the cap of the bottle.
  3. Tilt the head back and pull the lower lid of the eye out to form a pocket.
  4. Hold the container between the thumb and middle finger of the other hand, turn the container upside down near to the eye. Try not to touch the eye with the nozzle.
  5. Apply enough pressure to the container to release one drop.
  6. Close the eye, and keep the eye closed for a minute or two. If you think that you have missed the eye, then insert another drop.
  7. Repeat in the other eye if you have been instructed to use the drops in both eyes.
  8. Replace the cap on the container, trying not to touch the applicator tip with any surface, including the eye or the fingers.
  9. Wash your hands again.

Getting the most from your treatment

  • After instilling a drop in your eye, press on the area between your nose and just below the inner the corner of your eye for one minute - this reduces the chance of the medication being absorbed into your body.
  • If you are using several different eye drops, leave 5 - 15 minutes between using each drops.
  • Do not instil more than one drop - using several drops does not improve your glaucoma but will increase the risk of side effects.
  • If you wear contact lenses, leave a gap of at least 15 minutes after using your eye drops before putting your lenses in. These drops will discolour soft contact lenses.
  • Avoid driving or operating machinery if your vision is blurred.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment that you are using these eye drops.

Can brimonidine and timolol eye drops cause problems?

Along with their useful effects all medicines can cause unwanted side effects which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who use these dropsWhat can I do if I experience this
Dry eye, blurred vision, eye redness, burning, stinging, eye inflammation and irritationAvoid driving or operating machinery if your eyesight is blurred. If any of these continue or become troublesome, talk to your doctor
DrowsinessMake sure your reactions are normal before driving or operating machinery
HeadacheAsk your pharmacist for some pain relief. If the headache continues, speak to your doctor
Dryness in the mouthTry chewing sugar-free gum, or sucking boiled sweets

If you experience any other symptoms which you think may be due to these eye drops, speak with your doctor or pharmacist.

How to store brimonidine and timolol eye drops

  • Eye drops can be used for 4 weeks once the bottle has been opened. After this time use a new bottle.
  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

  • Manufacturer's PIL, Combigan®, Allergan Ltd, electronic Medicines Compendium. Dated May 2006, accessed November 2008.
  • British National Formulary; 56th Edition (September 2008) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF).
Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2008DocID: 9210DocRef: dils3945Last Reviewed: 15 Dec 2008Version: 1
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