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Atovaquone

  • Atovaquone is used to treat a lung infection called Pneumocystis jirovecii (carinii) pneumonia.
  • It is important to take this medicine with food, preferably food high in fat.
  • If diarrhoea becomes a problem, particularly when you first start your treatment, let your doctor know.
  • Complete the course even if you feel well.

About atovaquone

Type of medicineAntiprotozoal
Used forPneumocystis jirovecii (carinii) pneumonia
Also calledWellvone®
Available asOral suspension

Atovaquone is used to treat an infection of the chest and airways called Pneumocystis pneumonia (PCP) in people who cannot be treated with co-trimoxazole. PCP is caused by an organism called Pneumocystis jirovecii (which used to be called Pneumocystis carinii). Atovaquone works by killing this organism.

Before taking atovaquone

Before taking atovaquone make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have liver or kidney problems.
  • If you are over 65 years of age.
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.

How to take atovaquone

  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • Take atovaquone exactly as directed by your doctor. It is very important that you take your doses with food, preferably foods that are high in fat. This is because high-fat foods help your body absorb atovaquone and make your treatment more effective.
  • Try to take atovaquone at the same times each day to avoid missing any doses. It is usually taken twice-daily (morning and night-time) for 21 days. Remember to shake the bottle well before pouring out your dose.
  • If you forget to take a dose, take one as soon as you remember but do not take two doses together.

Getting the most from your treatment

  • You must complete the full course of atovaquone (even if you feel better) otherwise the infection may come back.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
  • If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Can atovaquone cause problems?

Along with their useful effects all medicines can cause unwanted side-effects. These usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
DiarrhoeaLet your doctor know about this particularly if it is at the start of your treatment. It may mean that your body is not absorbing the full dose of atovaquone which means the treatment could be less effective
Feeling or being sickEat little and often. Remember to take your doses with a meal
HeadacheAsk your pharmacist to recommend a suitable painkiller. If your headache continues, speak to your doctor
Difficulty sleeping, skin rash and itching, feverIf any of these become troublesome, speak with your doctor

Important: if you experience difficulty breathing or any swelling of the mouth, throat or face, speak with your doctor immediately or go to your local accident and emergency department without delay.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store atovaquone

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

  • Manufacturer's PIL, Wellvone® 750 mg/5 ml oral suspension; Manufacturer's PIL, Wellvone® 750mg/5ml oral suspension, electronic Medicines Compendium. Dated October 2008, accessed January 2010.
  • British National Formulary; 58th Edition (September 2009) British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2010DocID: 3790DocRef: dils3796Last Reviewed: 19 Apr 2010Version: 22
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