Raynaud's phenomenon occurs when the extremities of the body, usually the fingers and toes, change colour and may become painful. It is due to a narrowing (constriction) of the small blood vessels on exposure to the cold, or to a change in temperature, or to emotional stress. In most cases, the cause is not known. In some cases, it is a symptom of an underlying condition such as scleroderma, lupus, or rheumatoid arthritis. The main treatment is to keep warm. Medicines to open up the blood vessels are used in some cases.
What is Raynaud's phenomenon?
Raynaud's phenomenon, often just called Raynaud's, is a condition where the small blood vessels of the fingers become narrow (constrict), most commonly when they are in a cool environment. Sometimes blood vessels to other extremities such as the toes, ears and nose are affected. It is named after Dr Maurice Raynaud, the man who first described it in 1862.
What are the symptoms of Raynaud's?
Typically, symptoms develop in fingers when you become cool - for example, in cold weather.
- At first the fingers go white and cool. This happens because the small blood vessels in the fingers narrow (constrict).
- The fingers then go a bluish colour (or even purple or black in severe cases). This happens because the oxygen is used up quickly from the blood in the narrowed blood vessels.
- The fingers then go bright red. This happens because blood vessels open up again (dilate) and the blood flow returns. This may cause tingling, throbbing, numbness and pain (which can be severe in some cases).
Many people with Raynaud's do not have the full classic colour changes, but develop bouts of uncomfortable, pale, cold fingers. Only the fingers are affected in most cases. In some cases the toes are also affected. Less commonly other extremities of the body are affected, such as the earlobes, nose, nipples or tongue. Each bout of symptoms can last from minutes to hours.
Raynaud's is usually mild, with infrequent, brief bouts of symptoms that last just a few minutes. Sometimes it is moderate with more frequent bouts of symptoms that last longer. Rarely, it is severe with repeated frequent bouts, with each bout lasting longer periods of time.
What causes Raynaud's?
Primary Raynaud's - when the cause is not known
In most cases there is no known cause (more than 9 in 10 cases). This is called primary Raynaud's. The small blood vessels in the fingers, toes, etc, just appear to be more sensitive than normal to cool temperatures. There is no other underlying disease. Symptoms are triggered more easily in some people than in others. Even mildly cool weather, or getting something out of the freezer, can trigger symptoms in some people. Strong emotion may also trigger symptoms in some cases.
Usually, all fingers on both hands are affected in primary Raynaud's. It also tends to run in some families. Women are affected much more often than men. It usually first develops before the age of 30. There are no other symptoms apart from those described above, and symptoms go completely after each bout.
Secondary Raynaud's - due to an underlying cause
In less than 1 in 10 cases, there is an underlying cause. This is called secondary Raynaud's. Various conditions of blood vessels, joints, muscles, nerves or skin can cause secondary Raynaud's. For example, scleroderma, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus (SLE) and other 'connective tissue' diseases.
If you have secondary Raynaud's you will normally have other symptoms in addition to the symptoms of Raynaud's. The Raynaud's is just one feature of the condition. For example, you may also have joint pains, rashes, joint swelling, etc.
Often, the underlying condition is already present, and you may develop Raynaud's as a complication. Sometimes the symptoms of Raynaud's occur first, and other symptoms of the underlying condition develop weeks, months or even years later.
In secondary Raynaud's, symptoms may first begin in just one or two fingers on one hand. This is in contrast to primary Raynaud's when all fingers on both hands are typically affected. Certain medicines may also cause secondary Raynaud's as a side-effect (see below).
Hand-arm vibration syndrome (vibration white finger) is one common cause of secondary Raynaud's. This is caused by using vibrating tools regularly over a long time. For example, it occurs in some shipyard workers, mine workers, road diggers, etc. It is thought that repeated vibrations over time may damage the small blood vessels or their nerve supply.
How common is Raynaud's?
Raynaud's is a common disorder. About 1 in 20 people develop Raynaud's phenomenon. Up to 9 in 10 cases are primary Raynaud's. Primary Raynaud's usually first develops in teenagers and young adults, but it can develop at any age. Secondary Raynaud's can develop at any age when the underlying condition develops.
Do I need any tests to confirm the diagnosis?
Not in most cases. There is no test that confirms primary Raynaud's. The diagnosis of primary Raynaud's is made on the basis of the typical symptoms (described above) and there is no abnormality found that may suggest a secondary cause when a doctor examines you.
Features that may suggest secondary Raynaud's include:
- Onset of symptoms after 30 years of age.
- Abrupt onset with rapid progression and worsening of symptoms.
- Severe symptoms that may include an ulcer or gangrene of part of a finger or toe.
- Symptoms that only affect one hand or foot, or the symptoms are not the same or as severe on both hands and feet.
- Joint pains or arthritis.
- Skin rashes.
- Dry eyes or mouth.
- Muscle weakness or pain.
- Swallowing difficulties.
- Mouth ulcers.
- Previous work with vibrating tools.
Blood tests and other tests may be done if secondary Raynaud's is suspected. Sometimes the diagnosis of an underlying cause is already known (for example, rheumatoid arthritis) and the development of Raynaud's is not a surprising feature.
What are the possible complications of Raynaud's?
- Primary Raynaud's - complications seldom, if ever, occur.
- Secondary Raynaud's - complications occur in a small number of cases and include ulcers developing on affected fingers and toes; scarring of tips of fingers and toes; tissue death (gangrene) of parts of affected fingers and toes.
What can I do to help?
- Smoking can make symptoms worse. The chemicals in tobacco can cause the small blood vessels to narrow. If you smoke, stopping smoking may ease or even cure the problem.
- Some medicines that are used to treat other conditions sometimes trigger symptoms or make them worse. The medicine may cause the blood vessels to narrow. Such medicines include beta-blockers, some anti-migraine medicines, decongestants, and, very occasionally, the contraceptive pill. Don't stop a prescribed medicine if you suspect it may be making symptoms worse. See your doctor to discuss possible alternatives.
- Other drugs. Caffeine (in tea, coffee, cola and in some painkillers) triggers symptoms in some people. Try cutting out caffeine for a few weeks to see if it helps. Amfetamines and cocaine may also be a trigger.
- Try to keep warm in cool weather or in cool environments:
- Keep your hands and feet warm. Warm gloves, socks and shoes are essential when you are out in cool weather.
- Keep your whole body warm, not just your hands and feet. Although your hands and feet are the most important, symptoms are less likely to occur if you keep your entire body warm. So, wrap up warmly before going into cooler areas, such as outside on cold days. For example, wear hats and scarves in addition to warm clothes.
- It is best to put on the gloves when you are warm, before going into colder areas. Ideally, keep gloves, socks and headgear in an airing cupboard or near a radiator so they will be warm when put on.
- If you have severe symptoms, or symptoms that are easily triggered, then portable heat packs and battery-heated gloves and socks are useful. The Raynaud's and Scleroderma Association has a list of suppliers - see below for their details. Your pharmacist or local medical supplier may also be able to advise.
- Try not to touch cold objects. For example, use a towel or gloves when removing food from the freezer or working with cold food.
- Regular exercise is recommended by many experts. Exercise your hands and feet frequently to improve the circulation.
- When a bout of symptoms develops, warm the affected hands or feet as soon as possible. Soaking the hands or feet in warm running water is a good way to get warm (but take care that the water does not become too hot, or lose its heat and become cool).
What treatments can help prevent Raynaud's symptoms?
Keeping warm is the main treatment. Symptoms are much less likely to occur, and be less severe, if you keep warm (described above). Other treatments are needed only in some cases.
A calcium-channel blocker called nifedipine may be advised if symptoms are severe. It works by 'opening up' (dilating) the small blood vessels. Some people take nifedipine regularly, each day, to prevent symptoms. Some people take nifedipine just during the winter, or just during cold weather spells. If you are prescribed nifedipine, read the leaflet that comes in the packet for a full list of possible side-effects and cautions. Some main points about nifedipine include:
- Most people do not get any side-effects, or only minor side-effects. Of the side-effects that may occur, the most common are headache, flushing, feeling sick (nausea) and dizziness.
- Nifedipine should not be taken by:
- Pregnant women or breast-feeding women.
- People with myocardial infarction, aortic stenosis, heart failure, peripheral oedema, symptomatic low blood pressure, and unstable angina.
- A lower dose may be required in the elderly and in people with severe liver disease.
- Do not drink grapefruit juice if you take nifedipine. The two can combine to make you unwell.
- If you also take a medicine called rifampicin it may reduce how well nifedipine works.
- You need your blood pressure monitored if you take both a beta-blocker medicine and nifedipine.
Various other medicines may be tried if nifedipine is not helpful, or causes side-effects. In particular, various medicines have been tried to some effect for people with secondary Raynaud's due to certain conditions.
Stress counselling or relaxation techniques
These may be helpful if you have primary Raynaud's and the symptoms are triggered by stress or emotion.
Treatment for an underlying condition
May be needed if you have secondary Raynaud's.
'Nerve blocks' or other hospital-based treatments
May be tried if you have severe Raynaud's which is not helped by other treatments.
What is the outlook (prognosis)?
The outlook for people with primary Raynaud's is usually good. Most people have mild symptoms that do not interfere much with daily life. People with more severe symptoms often respond well to treatment with nifedipine. In some cases the condition goes away (remits) in time. In one study that followed up people with primary Raynaud's over seven years, the condition had gone away in nearly 2 in 3 cases at some point over the study period.
Sometimes, someone who is thought to have primary Raynaud's develops other symptoms several months or years later and the diagnosis is changed to secondary Raynaud's. This is thought to occur in about 1 in 10 people who are initially diagnosed with primary Raynauds.
There are various underlying conditions that can cause secondary Raynaud's and their severity can vary. In general, symptoms are often more severe than with primary Raynaud's, and tend to respond less well to treatment. In some situations, treating an underlying condition will ease the symptoms of Raynaud's.
Further help & information
Further reading & references
- Raynaud's phenomenon; NICE CKS, June 2009
- Goundry B, Bell L, Langtree M, et al; Diagnosis and management of Raynaud's phenomenon. BMJ. 2012 Feb 7;344:e289. doi: 10.1136/bmj.e289.
- Hansen-Dispenza H et al; Raynaud Phenomenon, Medscape, Sep 2011
Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.
|Original Author: Dr Tim Kenny||Current Version: Dr Colin Tidy||Peer Reviewer: Dr Helen Huins|
|Last Checked: 28/03/2013||Document ID: 4321 Version: 39||© EMIS|
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