Proton Pump Inhibitors

Proton pump inhibitors (PPIs) reduce the amount of acid made by your stomach. They are commonly used to treat acid reflux and ulcers of the stomach and duodenum. Most people who take a PPI do not develop any side-effects.

Proton pump inhibitors (PPIs) are a class (group) of drugs that work on the cells that line the stomach, reducing the production of acid. They include: esomeprazole, lansoprazole, omeprazole, pantoprazole and rabeprazole, and come in various different brand names.

upper GI tract

PPIs are commonly used:

  • To treat ulcers in the stomach and duodenum (part of the gut).
  • To reduce acid reflux which may cause heartburn or oesophagitis (inflammation of the gullet). These conditions are sometimes called gastro-oesophageal reflux disease (GORD).
  • As one part of treatment to get rid of Helicobacter pylori - a bacterium (germ) found in the stomach, which can cause ulcers.
  • To help prevent and treat ulcers associated with anti-inflammatory medicines called non-steroidal anti-inflammatory drugs (NSAIDs).
  • In a rare condition called Zollinger-Ellison syndrome.
  • In other conditions where it is helpful to reduce acid in the stomach.

PPIs usually work very well to reduce stomach acid and to treat the above conditions. They have made a big impact on the quality of life of many people with these conditions since they first became available in the 1980s. They are commonly prescribed.

Your stomach normally produces acid to help with the digestion of food and to kill bacteria. This acid is corrosive so your body produces a natural mucous barrier which protects the lining of the stomach from being eroded.

In some people this barrier may have broken down allowing the acid to damage the stomach, causing an ulcer. In others there may be a problem with the muscular band at the top of the stomach (the sphincter) that keeps the stomach tightly closed. This may allow the acid to escape and irritate the oesophagus (gullet). This is called 'acid reflux' which can cause heartburn and/or oesophagitis.

PPIs stop cells in the lining of the stomach producing too much acid. This can help to prevent ulcers from forming or assist the healing process. By decreasing the amount of acid, they can also help to reduce acid reflux-related symptoms such as heartburn.

They are called 'proton pump inhibitors' because they work by blocking (inhibiting) a chemical system called the hydrogen-potassium adenosine triphosphatase enzyme system (otherwise known as the 'proton pump'). This chemical system is found in the cells in the stomach lining that make stomach acid.

Most of these medicines are prescription only. You can buy omeprazole and pantoprazole over the counter at pharmacies. However, if you need to use this medicine for more than four weeks you should consult your doctor.

Your doctor will advise you of the dose needed and how often you should take it. Some of these medicines need to be taken in a certain way, such as on an empty stomach. Therefore, read the leaflet that comes with your particular brand for further information.

Generally, PPIs are well absorbed by the body and may provide quick relief for some problems. For example, heartburn caused by acid reflux. However, if you are taking them for other reasons, such as to heal an ulcer, it may take longer for the medicines to have an underlying effect.

This can vary depending on the reason you are taking a PPI. So, speak to your doctor for advice. For example, in some cases your doctor may prescribe a PPI that you only take 'as required' to relieve your symptoms, rather than every day. In some cases a regular dose taken each day is advised.

It is possible that your symptoms might come back if you stop your drug. If this happens, see your doctor again.

PPIs may not be suitable for some people. For example, people with certain liver problems, or pregnant (but omeprazole is deemed to be safe) or breast-feeding mums. A full list of individuals who should not take a PPI is included with the information leaflet that comes in the medicine packet. If you are prescribed or buy a PPI, read this to be sure you are safe to take it.

Most people who take a PPI do not have any side-effects. However, side-effects occur in a small number of users. The most common side-effects are:

  • Constipation
  • Diarrhoea
  • Flatulence
  • Headaches
  • Nausea (feeling sick)
  • Abdominal (tummy) pain
  • Vomiting

For a full list of possible side-effects and cautions, see the leaflet that comes in the packet with your particular brand.

In particular: tell your doctor if you are taking the blood-thinning medicine warfarin, or a medicine for epilepsy, called phenytoin (Epanutin®), or medicines called digoxin, methotrexate and cilostazol. Taking a PPI can affect how well these medicines work, or can even cause serious 'drug reactions'. Also, lansoprazole possibly affects how well oral contraceptives might work. Discuss this with your doctor if it is relevant to you.

If you are taking antacids you should try to avoid taking them at the same time as you take your other medication, including PPIs. This is because antacids can affect how well your medication is absorbed.

If you think you have had a side-effect to one of your medicines you can report this on the Yellow Card Scheme. You can do this online at the following web address: www.mhra.gov.uk/yellowcard.

The Yellow Card Scheme is used to make pharmacists, doctors and nurses aware of any new side-effects that medicines may have caused. If you wish to report a side-effect, you will need to provide basic information about:

  • The side-effect.
  • The name of the medicine which you think caused it.
  • Information about the person who had the side-effect.
  • Your contact details as the reporter of the side-effect.

It is helpful if you have your medication - and/or the leaflet that came with it - with you while you fill out the report.

You should consult your doctor if your symptoms worsen, or if you experience any of the following problems which can indicate a serious gut disorder:

  • Vomiting blood. This may be obviously fresh blood, but altered blood in vomit can look like ground coffee. Doctors call this 'coffee-ground vomit'.
  • Blood in your stools (faeces). This may be obvious blood, or it may just make your stools black.
  • Unintentional weight loss.
  • Difficulty swallowing, including food getting stuck in the gullet.
  • Persistent abdominal pain or persistent vomiting.
Original Author:
Dr Tim Kenny
Current Version:
Peer Reviewer:
Dr Tim Kenny
Last Checked:
24/01/2012
Document ID:
9012 (v3)
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