If you do not have a spleen, or have a spleen that does not work well, you have an increased risk of developing some serious infections. The risk is reduced by: immunisation, taking regular low-dose antibiotics, and taking full-strength antibiotics as soon as the first sign of infection develops.
What is the spleen?
The spleen is an organ in the upper left side of the abdomen. It helps to protect against infections. As blood passes through the spleen, special cells kill bacteria that may be present.
Your spleen may be removed (splenectomy) for various reasons. For example, because of an illness that affects the spleen, or if it is damaged by an injury. Also, the spleen may not work well in some diseases - for example, sickle cell disease, thalassaemia, and lymphomas.
What is the risk without a spleen?
You can normally cope with most infections without a spleen. The spleen is just one part of the immune (defence) system. Other parts of the immune system protect against most bacteria, viruses, and other germs.
However, you have an increased risk of developing some serious infections if you do not have a spleen, or have a spleen that does not work properly. This complication is called overwhelming post-splenectomy infection (OPSI). The risk is small and OPSI is uncommon, but very serious and is often fatal if it occurs.
Examples of serious infections that you are at increased risk from if you do not have a working spleen are: pneumonia, meningitis, septicaemia (blood infection) and malaria.
What can I do to reduce the risk of infection?
Most infections that occur after splenectomy can be avoided through the following measures:
1. You should be immunised against the following:
- Pneumococcus. This bacterium is a common cause of serious chest infection. A booster is normally advised every five years.
- Haemophilus influenzae type b (Hib). This bacterium can cause chest infections and meningitis. Immunisation against Hib is now routine for all children. But, many adults will not have had it, so you may still need it if you did not have it as a child.
- The bacterium called meningococcus, which can cause meningitis. Immunisation is with the meningococcal ACWY conjugate vaccine. There are various strains of meningococcus. The meningococcal ACWY conjugate vaccine protects against four strains - A, C, W and Y.
- Influenza. The annual flu jab each autumn. The spleen is not needed to fight off the flu virus. However, some people with flu develop secondary chest infections from bacteria, which may lead to pneumonia. Therefore, it is best to prevent flu in the first place.
- Travelling abroad? Make sure that you have all the immunisations advised for the countries you visit. In particular, you should be immunised against Group A meningococcus if you are visiting certain hot counties where this is a risk. Also, see general information about travelling abroad below.
- Children should have all the other usual childhood immunisations apart from a variation in the meningococcal vaccine. That is, the meningococcal ACWY conjugate vaccine should be given instead of, or in addition to, the group C meningococcal vaccine, depending on the age of the child when the vaccines are given. Your doctor will advise exactly which meningococcal vaccine should be used and when. See separate leaflet called 'Immunisation - Usual UK Schedule' for more details.
If you are to have a planned operation to remove your spleen, then review your immunisation status with a doctor at least two weeks before surgery. In particular, the pneumoccocal and ACWY conjugate meningococcal immunisations are best given at least two weeks before the spleen is removed.
However, it is never too late. If you had your spleen removed in the past or you have been diagnosed as having a nonworking spleen, and are not immunised, get immunised as soon as possible.
Note: immunisation does not completely prevent the risk of infection. It only protects against certain types of infections.
2. You will probably be advised to take low-dose antibiotics every day for life
This advice is usual for most people without a working spleen. If you take a small dose of an antibiotic each day, it will prevent some serious infections. Penicillin is the usual antibiotic prescribed. Most people do not have any side-effects from the daily low dose. If you are allergic to penicillin, other antibiotics are available.
3. Keep a course of full-strength broad-spectrum antibiotics handy
Broad-spectrum antibiotics combat a wide range of bacteria. If you become ill with fever or other signs of infection, you should start a course of full-strength, broad-spectrum antibiotics straight away. This is in addition to taking regular low-dose penicillin (or similar). You should then get medical advice quickly.
Most feverish illnesses that you have will be common coughs and colds due to viral infections. These are not serious, and will be cleared by your immune system. The antibiotic will, in hindsight, usually not have been necessary. However, some serious infections start with symptoms similar to a cold. They can then develop quickly if you do not have a working spleen. So, it is best to play safe and take a course of full-strength broad-spectrum antibiotics as soon as any feverish illness starts and see a doctor promptly.
You have an increased risk of developing malaria, meningitis and babesiosis if you do not have a working spleen and come into contact with the germs causing these diseases. It may be best to avoid any countries where these diseases are common. In particular, a severe form of malaria is a concern for people without a spleen. Do you really need to travel? If you do travel, make sure you are fully immunised. Also, obtain up-to-date information about protecting against the type of malaria in the country you are to visit. This will include taking tablets to prevent malaria, and using mosquito nets, insect repellents, etc. Take the antimalarial tablets exactly as advised for maximum protection. This usually includes starting the tablets before you travel.
Also, take a course of broad-spectrum antibiotics with you. Contact your doctor before travelling. A change to a different regular antibiotic for the duration of the trip may also be advised, depending on which country you visit. This is because in some countries (for example, Spain) there is a high resistance to penicillin by some bacteria.
Other general advice
Animal and tick bites carry a risk of infection getting into the bloodstream. Take a course of full-strength broad-spectrum antibiotics after a bite, no matter how trivial. Also, consult a doctor urgently if you become ill after any bite. To help prevent tick bites whilst out in the countryside, wear clothing to cover exposed skin, especially long trousers to cover your legs.
Consider carrying a card or wearing a special bracelet or necklet which says that you do not have a working spleen. This would alert a doctor to take rapid action if you are seriously ill and cannot tell him or her yourself.
You can download a special card from the website of the Department of Health here.
Further reading & references
- Review of guidelines for the prevention and treatment of infections in patients with an absent or dysfunctional spleen, British Committee for Standards in Haematology (2011)
- Immunisation against infectious disease - the Green Book (latest edition); Public Health England
- Newland A, Provan D, Myint S; Preventing severe infection after splenectomy. BMJ. 2005 Aug 20;331(7514):417-8.
- Kyaw MH, Holmes EM, Chalmers J, et al; A survey of vaccine coverage and antibiotic prophylaxis in splenectomised patients in Scotland. J Clin Pathol. 2002 Jun;55(6):472-4.
- Waghorn DJ; Overwhelming infection in asplenic patients: current best practice preventive measures are not being followed. J Clin Pathol. 2001 Mar;54(3):214-8.
Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.
Dr Tim Kenny
Dr Gurvinder Rull
Dr Tim Kenny