Most cases of cancer of the larynx occur in people aged over 60. The common early symptom is a persistent hoarse voice. Many cases are diagnosed at an early stage when there is a good chance of a cure. In general, the more advanced the cancer (the more it has grown and spread), the less chance that treatment will be curative.
What is the larynx?
The larynx is the top part of the trachea (windpipe). It is about 5 cm long and is sometimes called the voice box. You can see and feel the front part of the larynx as the Adam's apple on the front of the neck, just below the chin.
The larynx contains the vocal cords. These are V-shaped ridges of muscle tissue on the inside lining of the larynx. They vibrate when air passes between them to produce speech.
When you breathe in, air passes into the larynx and down the trachea towards the lungs. When you swallow, the larynx moves upwards slightly and a flap of cartilage tissue at the back of the tongue, called the epiglottis, closes over the entrance to the larynx. This ensures that food or drink go down the oesophagus (gullet) and not down the trachea.
What is cancer?
Cancer is a disease of the cells in the body. The body is made up from millions of tiny cells. There are many different types of cell in the body, and there are many different types of cancer which arise from different types of cell. What all types of cancer have in common is that the cancer cells are abnormal and multiply 'out of control'.
A malignant tumour is a lump or growth of tissue made up from cancer cells which continue to multiply. As they grow, malignant tumours invade into nearby tissues and organs which can cause damage.
Malignant tumours may also spread to other parts of the body. This happens if some cells break off from the first (primary) tumour and are carried in the bloodstream or lymph channels to other parts of the body. These small groups of cells may then multiply to form secondary tumours (metastases) in one or more parts of the body. These secondary tumours may then grow, invade and damage nearby tissues, and spread again.
Some cancers are more serious than others, some are more easily treated than others, some have a better outlook (prognosis) than others.
So, cancer is not just one condition. In each case it is important to know exactly what type of cancer has developed, how large it has become, and whether it has spread. This will enable you to get reliable information on treatment options and outlook.
What is cancer of the larynx?
Cancer of the larynx is sometimes called laryngeal cancer. Some people also call it throat cancer. However, the throat includes the larynx and other nearby structures. Cancer of the larynx is just one type of cancer that can occur in the throat. Cancer of the larynx is uncommon in the UK with around 2,000 cases developing each year. It is four times more common in men than in women. It is rare in people aged under 40 years and is most common in people aged over 60 years.
There are different types of cancer of the larynx:
- Squamous cell carcinoma of the larynx occurs in more than 9 in 10 cases. This type arises from cells which are on the inside lining of the larynx.
- Other types. There are some rare types of cancer which arise from other types of cells within the larynx. For example, adenocarcinoma of the larynx arises from cells in the tiny glands in the wall of the larynx that make mucus. There are some other very rare types.
The rest of this leaflet is about squamous cell carcinoma of the larynx.
What causes cancer of the larynx?
A cancerous tumour starts from one abnormal cell. The exact reason why a cell becomes cancerous is unclear. It is thought that something damages or alters certain genes in the cell. This makes the cell abnormal and multiply out of control. (See separate leaflet called What Causes Cancer for more details.)
Some people develop cancer of the larynx for no apparent reason. However, certain risk factors increase the chance that cancer of the larynx may develop. These include:
- Ageing. It is more common in older people. Most cases are in people over 60.
- Smoking. The damaging smoke passes through the larynx to get to the lungs.
- Drinking a lot of alcohol, especially spirits.
- A poor diet may be a risk factor, especially a diet lacking certain vitamins and minerals.
- Long-term exposure to certain chemicals, fumes or pollutants may irritate the larynx if you breathe them in and may increase the risk.
- Human papillomavirus (HPV) has been shown in some studies to be associated with cancer of the larynx.
What are the symptoms of cancer of the larynx?
- A hoarse voice is often the first symptom because most cancers of the larynx first start on, or close by, a vocal cord. The problem is, a hoarse voice is a common symptom of laryngitis (a viral infection of the larynx). Most people with hoarseness do not have cancer. However, laryngitis usually clears within a week or so. Therefore, see a doctor if you develop a hoarse voice which does not go within 2-4 weeks.
- Other symptoms that may occur as the tumour grows in the larynx include: a lump in the throat, pain in the throat when swallowing, difficulty with breathing. These symptoms may occur before a hoarse voice develops if the tumour does not start next to the vocal cords.
- If the cancer spreads to local lymph nodes (lymph glands) then the nearby glands in the neck will swell.
- If the cancer spreads to other parts of the body, various symptoms can develop.
All the symptoms can be due to other conditions, so tests are needed to confirm the diagnosis.
How is cancer of the larynx diagnosed and assessed?
If a doctor suspects that you may have cancer of the larynx, he or she will refer you to an ear, nose and throat (ENT) specialist. The specialist will examine the inside of your throat by using a small mirror and light. He or she may also use a thin, flexible, telescope (a nasoendoscope). This is passed into your nose and down the back of your throat. The nasoendoscope contains fibre-optic channels, allowing light to shine down so the doctor can see inside. (The throat is usually sprayed with a local anaesthetic before using a nasendoscope so the procedure is not too uncomfortable.)
To confirm the diagnosis
If anything suspicious is seen by the examination or with the nasoendoscope, you will usually need a biopsy. A biopsy is when a small sample of tissue is removed from a part of the body. The sample is then looked at under the microscope to look for abnormal cells. The biopsy sample is obtained by a thin, flexible grabbing instrument which is passed through your nose into the larynx. The same instrument has a light source similar to a nasoendoscope and so the specialist will also examine the trachea and oesophagus to see the extent of any tumour.
Assessing the extent and spread (staging)
In addition to the above tests, if you are confirmed to have cancer of the larynx then further tests may be done; for example, biopsy samples may be taken from the nearby lymph glands by using a fine needle. This helps to assess if any cancer cells have spread to the lymph glands.
Other tests may be arranged to see if the cancer has spread to other parts of the body. For example, a CT scan, an MRI scan, or other tests. (The separate leaflets describe each of these tests in more detail.)
This assessment is called staging of the cancer. The aim of staging is to find out:
- How much the tumour in the larynx has grown.
- Whether the cancer has spread to local lymph nodes.
- Whether the cancer has spread to other areas of the body (metastasised).
Grade of the cancer
The biopsy samples are looked at under the microscope to asses the cancer cells. By looking at certain features of the cells the cancer can be graded.
The common grading system used for cancer of the larynx is:
- Grade 1 (low grade). The cells look reasonably similar to normal cells in the larynx. The cancer cells are said to be well differentiated. The cancer cells tend to grow and multiply quite slowly and are not so aggressive.
- Grade 2 (intermediate grade).
- Grade 3 (high grade). The cells look very abnormal and are said to be poorly differentiated. The cancer cells tend to grow and multiply quite quickly and are more aggressive.
By finding out the stage and grade of the cancer it helps doctors to advise on the best treatment options. It also gives a reasonable indication of outlook (prognosis). However, for cancer of the larynx, it may not be possible to give an accurate staging until after an operation to remove the tumour.
(See separate leaflet called Staging and Grading Cancer for more details.)
What are the treatment options for cancer of the larynx?
Treatment options which may be considered include radiotherapy, surgery, and chemotherapy. The treatment advised for each case depends on various factors such as the exact site of the primary tumour in the larynx, the stage of the cancer (how large the cancer is and whether it has spread), the grade of the cancerous cells, and your general health.
You should have a full discussion with a specialist who knows your case. They will be able to give the pros and cons, likely success rate, possible side-effects, and other details about the possible treatment options for your type of cancer.
You should also discuss with your specialist the aims of treatment. For example:
- In some cases, treatment aims to cure the cancer. There is a good chance of a cure if it is treated in the early stages. Many cases are diagnosed at an early stage. This is because tests are usually done if you develop a persistent hoarse voice which often develops when the cancer is still at an early stage. (Doctors tend to use the word remission rather than the word cured. Remission means there is no evidence of cancer following treatment. If you are in remission, you may be cured. However, in some cases a cancer returns months or years later. This is why doctors are sometimes reluctant to use the word cured.)
- In some cases, treatment aims to control the cancer. If a cure is not realistic, with treatment it is often possible to limit the growth or spread of the cancer so that it progresses less rapidly. This may keep you free of symptoms for some time.
- In some cases, treatment aims to ease symptoms. For example, if a cancer is advanced then you may require painkillers or other treatments to help keep you free of pain or other symptoms. Some treatments may be used to reduce the size of a cancer, which may ease symptoms such as pain or difficulty with swallowing.
This is the common treatment if the cancer is small and has not spread from the larynx (early stage). Radiotherapy is a treatment which uses high-energy beams of radiation which are focused on cancerous tissue. This kills cancer cells, or stops cancer cells from multiplying. (See separate leaflet called Radiotherapy for more details.)
Radiotherapy alone gives a good chance of a cure if the cancer is at an early stage. Radiotherapy is also sometimes used in addition to surgery or chemotherapy in certain situations. For example, radiotherapy may be used to shrink a large tumour prior to surgery. This may give a better chance of success with surgery. It is sometimes used following surgery, to kill any cancer cells which may have been left behind following the operation.
Tumours which are larger tend to require surgery. Sometimes surgery is aimed at curing the cancer by removing it all. Sometimes surgery is used to relieve symptoms if the cancer is at an advanced stage (palliative surgery). The operations are all done whilst you are asleep under a general anaesthetic.
The type of operation done depends on the size of the tumour, the exact site of the tumour in the larynx, and whether the cancer has spread to nearby structures or lymph glands. For example:
- Endoscopic resection. This is a technique which can remove a small tumour in the larynx. Instruments are passed down the inside of the larynx which cut out a tumour. Sometimes a laser is used to burn out the tumour. This technique does not involve a cut from the outside. It is only suitable for tumours that are small and still confined to the inner lining of the larynx.
- Partial laryngectomy. This is an operation where the affected part of the larynx is cut out. A cut is made in the front of the neck to get at the larynx. If only part of the larynx is removed you should not need a permanent stoma (hole in the neck) to breathe, and speech may be preserved. A temporary stoma may be required whilst the wound is healing.
- A total laryngectomy. This is an operation where the entire larynx is removed. To be able to breathe after the operation, the top part of the trachea is attached to the front of the neck. You will then have a permanent hole (stoma) in the front of the neck. The vocal cords will have been removed so you will not be able to speak normally again. However, there are various techniques that you can be taught by a speech therapist which can enable you to make sounds and speak in a different way.
If the cancer has spread, the surgeon may also remove lymph glands and other structures near to the larynx in addition to removing the larynx. The amount of tissue removed depends on the extent of local spread of the cancer.
Chemotherapy is a treatment which uses anti-cancer drugs to kill cancer cells, or to stop them from multiplying. Chemotherapy used in conjunction with radiotherapy is sometimes used as an alternative to surgery. It aims to preserve the larynx and normal speech. Your specialist will advise when this may be an option. Chemotherapy may also be advised if the cancer has spread to other areas of the body. (See separate leaflet called Chemotherapy with Cytotoxic Medicines for more details.)
Cetuximab is a fairly new treatment for laryngeal cancer. It is a type of monoclonal antibody which means that it can recognise and bind to specific proteins (receptors) that are found in the cancer cells. These proteins are epidermal growth factor receptors (EGFRs) which stimulate the cancer cell to grow and divide. Cetuximab locks on to the EGFR and can prevent the cancer cells from growing and dividing.
Cetuximab is a treatment that is usually given at the same time as radiotherapy in people who are unable to have chemotherapy.
What is the prognosis (outlook)?
If a cancer of the larynx is diagnosed and treated at an early stage then there is a good chance of a cure. A cure is less likely if the cancer has spread.
The treatment of cancer is a developing area of medicine. New treatments continue to be developed and the information on outlook above is very general. The specialist who knows your case can give more accurate information about your particular outlook, and how well your type and stage of cancer is likely to respond to treatment.
Further help and information
Cancer Laryngectomee Trust
PO Box 618, Halifax, West Yorkshire, HX3 8WX
Tel: 01422 205522 Web: www.cancerlt.org
Provides support for people who are about to have, or have had, a laryngectomy.
Macmillan Cancer Support
Tel (Helpline): 0808 808 0000 Web: www.macmillan.org.uk
Provide information and support to anyone affected by cancer.
Web: http://cancerhelp.cancerresearchuk.org provides facts about cancer, including treatment choices.
Other support groups
See Patient.co.uk Cancer/Leukaemia/Lymphoma support groups.
Further reading & references
- Head and neck cancer - cetuximab, NICE Technology Appraisal Guidance (June 2008)
- Johnson JT et al, Malignant Tumors of the Larynx, Medscape, May 2012
- Agrawal N, Ha PK; Management of early-stage laryngeal cancer. Otolaryngol Clin North Am. 2008 Aug;41(4):757-69, vi-vii.
- Koukourakis G, Kouloulias V, Koukourakis M, et al; The efficacy of combined treatment with cetuximab (erbitux) and radiation therapy in patients with head and neck cancer. J BUON. 2009 Jan-Mar;14(1):19-25.
- Giuliano AR, Tortolero-Luna G, Ferrer E, et al; Epidemiology of human papillomavirus infection in men, cancers other than cervical and benign conditions. Vaccine. 2008 Aug 19;26 Suppl 10:K17-28.
|Original Author: Dr Tim Kenny||Current Version: Dr Colin Tidy||Peer Reviewer: Dr John Cox|
|Last Checked: 14/08/2012||Document ID: 4865 Version: 38||© EMIS|
Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.