Bullous pemphigoid is a skin disease that causes blisters. It mainly affects people aged over 70. Treatment usually works well to control symptoms. Treatment is usually with steroid creams or medicines, but sometimes other medicines may be used. The condition tends to go away after 1-5 years and then treatment can be stopped. Sometimes the disease persists and treatment is needed long-term.
What is bullous pemphigoid?
Bullous pemphigoid is a skin condition that causes blisters. In some cases the condition becomes severe and serious.
Note: several skin conditions cause blisters and it is important to know exactly which disease you have. They have similar sounding names - for example, pemphigus vulgaris and other types of pemphigus. These different blistering conditions vary greatly in their seriousness, outlook and treatment. For example, see separate leaflet called Pemphigus Vulgaris (which tends to be a more serious disease than bullous pemphigoid).
This leaflet is only about bullous pemphigoid - shortened to BP from now on.
Who gets bullous pemphigoid?
Bullous pemphigoid (BP) is rare. In the UK it is estimated that between 4-5 people in 100,000 develop it each year. Most people with BP are aged over 70. It is very rare in children. BP is not infectious and you cannot catch it from an affected person.
What causes bullous pemphigoid?
BP is an autoimmune disease. The immune system normally makes antibodies to attack bacteria, viruses, and other germs. In people with autoimmune diseases, the immune system also makes antibodies against a part or parts of the body.
In people with BP, antibodies are made against the membrane between the top layer of skin (the epidermis) and the next layer (the dermis). This antibody attack causes fluid to build up as blisters between these two layers of skin.
It is not known why BP or other autoimmune diseases occur. It is thought that something triggers the immune system to attack the body's own tissues. Certain conditions and medications have been linked to BP, but they are not thought to cause it. They may be trigger factors. They include: diseases such as ulcerative colitis and multiple sclerosis; medications such as furosemide, non-steroidal anti-inflammatory drugs (NSAIDs), captopril, penicillamine and some antibiotics; other factors such as ultraviolet radiation and radiotherapy.
What are the symptoms of bullous pemphigoid?
The first symptoms may be small patches of itchy skin. There may also be a pink rash which can look like eczema. Blisters then develop a week or more later. In some cases, the blisters do not start until months later.
The blisters are quite firm and dome-shaped. The blister fluid is usually clear, but may be cloudy or blood-stained. Any area of skin can be affected, but blisters mostly occur on the arms, legs, armpits and groin. The amount of blistering can vary: sometimes it is just one area, such as the lower leg. In severe cases, the whole body may be affected.
The skin over the blisters is quite strong. It may be several days before the blister bursts. A raw patch of skin is left when a blister bursts, which then heals. Some blisters do not burst, instead the fluid is absorbed into the body and the roof of the blister settles back down on the skin. The blisters usually heal without forming scars.
Some people with BP get small blisters inside the mouth. The blisters can break to form erosions which look like mouth ulcers.
BP may be itchy. The amount of itch can vary from severe to none at all.
How does bullous pemphigoid progress?
If untreated, the blisters and raw areas of skin can cause much discomfort. There is a danger of serious infection occurring on raw areas of skin. BP commonly lasts 1-5 years and then often eases or goes away. Future recurrences may occur, but these tend to be milder.
How is bullous pemphigoid diagnosed?
The diagnosis may not be clear at first. There are other causes of skin blisters and mouth erosions. Also, the early symptoms (before blisters appear) may look like eczema or allergy. If your doctor suspects that you have BP, they will refer you to a skin specialist. Tests are usually done to confirm the diagnosis. These are:
- A biopsy (a small sample) of skin may be taken. This is looked at under the microscope and tested to confirm that the blisters are due to BP.
- A blood test can detect the antibody that causes BP (the BP auto-antibody). The antibody may also be detected in urine or in blister fluid.
What is the treatment of bullous pemphigoid?
Treatment involves suppressing the immune process, so that itching and blistering are reduced. The aim is to find the right balance of treatment. You need to feel comfortable and not have many blisters, but without too many side-effects of treatment. Usually the best balance is the point where there may be a few blisters or symptoms which you can tolerate. This may be better than totally suppressing all symptoms, which could mean using large amounts of treatment and having more side-effects. Treatments used for BP are:
Steroid creams, also called topical steroids, are a safe and effective treatment for BP. High-strength steroid creams will normally be needed. Research suggests that steroid creams are a good option for most types of BP, even the more severe forms. This research also suggests that certain steroid creams are more effective than steroid tablets, have fewer side-effects and give better results overall.
Steroid tablets such as prednisolone are also used as treatment for BP. They are used when the rash is widespread, or there are practical problems applying the cream. Steroids reduce inflammation and suppress the immune system. The dose of steroid depends on how severe the BP is. A medium or high dose is usually needed at first, and the dose can then be reduced once the blisters clear up. The aim is to find the lowest dose needed to control symptoms, which varies from person to person.
Steroid creams and tablets can be used together, and this may mean that a lower dose of tablets can be used. Treatment is usually needed for between 6 months and 4 years. BP tends not to return after that.
All steroids, whether tablets or creams, can have side-effects. Side-effects from steroids can sometimes be serious, especially if you take high-dose steroids for a long time. For example, you are more prone to certain infections if you take regular high-dose steroids. Another side-effect is osteoporosis (thinning of the bones). If you take steroid treatment for more than a month, you will probably be advised to take vitamin D and calcium tablets to help prevent osteoporosis. You should be aware that long-term steroid treatment should not be stopped suddenly. See separate leaflet called 'Oral Steroids' for more details.
There are some other treatments which can help with BP. These are:
- Skin treatments such as dressings and wound care, which will be needed if you have areas of raw skin.
- Medicines called dapsone and sulphonamides, which are sometimes used if steroids have not been effective. They tend to cause more side-effects and so are not used as often as steroids.
- A newer medication called rituximab, which has been useful in difficult-to-treat cases.
What is the outlook (prognosis)?
The outlook is generally good. BP often goes away after 1-5 years, and meanwhile, treatment usually keeps the blisters away or down to a tolerable level. Often, treatment can be stopped after about 1-5 years, as it is no longer needed.
BP can sometimes cause serious illness, which may cause death. This is because:
- Serious infection of raw skin is dangerous. BP most commonly affects older people, who are more prone to develop serious illness if a skin infection occurs.
- Side-effects from steroids may be a problem and can sometimes be serious.
Further reading & references
- Welsh B; Blistering skin conditions. Aust Fam Physician. 2009 Jul;38(7):484-90.
- Kirtschig G, Middleton P, Bennett C, et al; Interventions for bullous pemphigoid. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD002292.
- Gurcan HM, Ahmed AR; Efficacy of dapsone in the treatment of pemphigus and pemphigoid: analysis of Am J Clin Dermatol. 2009;10(6):383-96. doi: 10.2165/11310740-000000000-00000.
- Hertl M, Bernard P, Borradori L; Rituximab for severe mucous membrane pemphigoid: safe enough to be drug of first Arch Dermatol. 2011 Jul;147(7):855-6.
- Guidelines for the management of bullous pemphigoid, British Association of Dermatologists (2012)
Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.
|Original Author: Dr Tim Kenny||Current Version: Dr Hayley Willacy||Peer Reviewer: Dr Tim Kenny|
|Last Checked: 21/02/2012||Document ID: 4514 Version: 41||© EMIS|
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