Dupuytren's contracture causes thickening of tissues in the palm. If it progresses, one or more fingers bend (contract) into the palm and you cannot straighten the finger. The cause is not known. In many cases it remains mild and does not require treatment. If the condition becomes more severe or the function of the hand becomes affected then a specialist may recommend treatment.
What is Dupuytren's contracture?
Dupuytren's contracture is a condition of the hands and fingers. It is sometimes called Dupuytren's disease because not everyone with this condition develops contractures.
At first, there is a thickening of some tissues under the skin in the palm. If the disease progresses you may develop a contracture of one or more fingers. A contracture is when affected fingers bend (contract) towards the palm and you cannot straighten them fully. Typically, the ring finger is usually affected first. Then the little finger, and then the middle finger. It takes months or years for the condition to develop and progress to a contracture.
Dupuytren's contracture is not usually painful. The main problem is that if one or more contractures develop, you cannot use the affected fingers properly. The extent of a contracture varies greatly from mild to severe. Sometimes just one hand is affected. Commonly, it affects both hands.
Some people with Dupuytren's contracture have some thickened tissue under the skin in other parts of their body. For example, a thickening on the knuckles, on the soles of the feet, or on the penis.
The picture shows a severe contracture of the little finger and a mild contracture of the ring finger. You can also see some thickening of the tissues under the skin in the palm.
What causes Dupuytren's contracture?
The tissue called the connective tissue in the affected palm becomes thick and abnormal. This is the tissue just under the skin but above the tendons. This forms into bands of thick tissue which, when it gets worse, pulls the fingers towards the palm. The abnormal tissue that forms is similar to scar tissue that forms following a wound.
The reason why this tissue becomes thickened is not known. There seems to be a genetic factor as it has a tendency to run in some families and it is more common in some countries - mainly northern European. It is more common in people with diabetes, epilepsy, and alcohol dependence - but most people with Dupuytren's contracture do not have any of these other conditions. In some cases it is thought that an injury to the hand may trigger the condition to start in someone who is genetically prone to develop the condition.
However, in most people with Dupuytren's contracture, there is no known cause or associated illness or injury. It is not due to your type of job, vibrating tools, manual work, or other working environments.
Who gets Dupuytren's contracture?
Dupuytren's contracture is named after Baron Dupuytren who described the condition in 1831. He thought it was due to many years of holding on to the reins of a horse! This is obviously not the cause as it remains a common condition. Most cases occur in middle-aged or older people, but it sometimes develops in younger adults. It is more common in men than women, and is most commonly found in people of European descent. About 1 in 6 men in the UK over the age of 65 have some degree of Dupuytren's contracture.
Do I need treatment?
Treatment is needed only if the normal function of the hand is affected - or is likely soon to become affected.
Many people with Dupuytren's contracture do not need any treatment. In many cases the condition remains mild and causes little interference with the use of the hand. There may be just thickened tissue, or thickened tissue with a mild contracture. In these situations no treatment is usually advised. Also, in about 1 in 10 cases, the condition improves without any treatment. However, the condition does tend to worsen over time in some cases. The need for treatment can be reviewed from time to time.
As a general rule, your GP will refer you to a hand specialist for assessment if you are not able to place your hand flat on a table top or if your hand function is significantly affected. The specialist may consider nonsurgical or surgical options for treatment. The aims of treatment are to restore hand function and prevent progression of the disease.
Nonsurgical treatment options
Nonsurgical treatments tend to be mainly considered if the contracture is mild and not causing too much of a problem.
Simple splinting of the hand is sometimes tried but the effectiveness of this is debatable.
Treatments that have recently been studied include injecting a treatment drug (an intralesional injection) into the thickened tissue. These aim to counteract the process that causes tissue thickening. Initial trails of injections with collagenase, steroids and 5-fluorouracil have been promising. Some doctors use one of these injections, particularly if the contracture is not too advanced. However, further research is needed to clarify the role of these treatments.
Radiation therapy for Dupuytren's contracture consists of having several low doses of X-rays to the affected hand. The theory is that this will soften the abnormal tissue which will then stop or slow down the progression of the disease. There is some uncertainty about how well this treatment works. However, some research studies suggest that there is a reasonable chance of this treatment working well. Some people develop side-effects following treatment, such as dry skin on the hands. Also, as with any type of radiation therapy, there is a theoretical risk that cancer might develop in the treatment tissue in the long-term (although this is thought to be very unlikely). Your specialist will be able to advise on the pros and cons of trying this treatment.
Surgical treatments for Dupuytren's contracture
As a general rule, a specialist may recommend a treatment to straighten out the affected finger or fingers if:
- There is a contracture of 30-40° or more at a joint between the palm and a finger (a metacarpophalangeal (MCP) joint).
- There is a contracture of 10-20° or more between one of the small joints in a finger. Surgery 'earlier than later' may be recommended if the bend (contracture) is affecting the first joint within the finger itself, as it is more difficult to correct this with the passing of time.
There are three main types of surgical procedure:
Fasciotomy simply means cutting the thickened tissue. (Another word for the thickened tissue is called fascia.) Open fasciotomy means that to get to the thickened tissue, the overlying skin is cut open. This allows the surgeon to see the thickened tissue, and then to cut it. The skin is then stitched back together. It is a relatively minor procedure which can be done under local anaesthetic as a day case.
This is sometimes called needle aponeurotomy or closed fasciotomy. What happens is that the specialist pushes a fine needle through the skin over the contracture. He or she then uses the sharp bevel of the needle to cut the thickened tissue under the skin. In effect, the needle acts like a saw as the specialist moves the needle to and fro to saw through the thickened tissue. The procedure is done under local anaesthetic and can be done in an outpatient clinic.
Needle fasciotomy has received quite a bit of press coverage as it sounds like an easy, quick procedure with minimal intervention. However, it is not always suitable. This is because:
- It is mainly suitable where the contracture is away from important nerves in the hand.
- It tends not to be suitable for severe contractures.
- There is a good chance it will not be of benefit in the long-term. The contracture returns in about half of cases within 3-5 years following this procedure. (But, if it does return, the procedure may be able to be repeated.)
- As the specialist cannot see the end of the needle once it is inserted, there is a risk of damage to nearby tendons, blood vessels and nerves, which can cause long-term problems.
Needle fasciotomy tends to be mainly suitable for older patients who are unsuitable for more definitive curative surgery, and in some cases where the contracture is in certain sites. Your specialist will advise if it is an option for you.
This means removing the abnormal thickened tissue. This is a more extensive hand operation. However, it gives the best chance of a long-term cure. It is the most commonly done procedure to treat Dupuytren's contracture.
Remember, all surgical procedures (operations) carry a risk. There is a small risk of damage to nearby tendons, blood vessels and nerves during any of the above procedures, and of infection developing in the hand.
Further reading & references
- Needle fasciotomy for Dupuytren's contracture, NICE (2004)
- Dupuytren's disease, Clinical Knowledge Summaries (May 2010)
- Radiation therapy for early Dupuytren's disease, NICE Interventional Procedure Guideline (November 2010)
- Trojian TH, Chu SM; Dupuytren's disease: diagnosis and treatment. Am Fam Physician. 2007 Jul 1;76(1):86-9.
- Townley WA, Baker R, Sheppard N, et al; Dupuytren's contracture unfolded. BMJ. 2006 Feb 18;332(7538):397-400.
- Dupuytren's Contracture, Wheeless' Textbook of Orthopaedics
- Foucher G, Medina J, Navarro R; Percutaneous needle aponeurotomy: complications and results. J Hand Surg (Br). 2003 Oct;28(5):427-31.
- Badalamente MA, Hurst LC, Hentz VR; Collagen as a clinical target: nonoperative treatment of Dupuytren's disease. J Hand Surg [Am]. 2002 Sep;27(5):788-98.
- Ketchum LD, Donahue TK; The injection of nodules of Dupuytren's disease with triamcinolone acetonide. J Hand Surg [Am]. 2000 Nov;25(6):1157-62.
- Bulstrode NW, Mudera V, McGrouther DA, et al; 5-fluorouracil selectively inhibits collagen synthesis. Plast Reconstr Surg. 2005 Jul;116(1):209-21; discussion 222-3.
|Original Author: Dr Tim Kenny||Current Version: Dr Tim Kenny|
|Last Checked: 05/01/2011||Document ID: 4237 Version: 39||© EMIS|
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