Kidney Cancer

What are the kidneys?

• Renin - which helps to regulate blood pressure.
• Erythropoietin - which helps to stimulate the bone marrow to make red blood cells.
• Calcitriol - which helps to regulate the calcium level in the blood.

Although it is normal to have two kidneys, we can live perfectly well with just one healthy kidney.

What is cancer?

Cancer is a disease of the cells in the body. The body is made up from millions of tiny cells. There are many different types of cell in the body, and there are many different types of cancer which arise from different types of cell. What all types of cancer have in common is that the cancer cells are abnormal and multiply 'out of control'. A malignant tumour is a 'lump' or 'growth' of tissue made up from cancer cells which continue to multiply. Malignant tumours invade into nearby tissues and organs which can cause damage.

Malignant tumours may also spread to other parts of the body. This happens if some cells break off from the first (primary) tumour and are carried in the bloodstream or lymph channels to other parts of the body. These small groups of cells may then multiply to form 'secondary' tumours (metastases) in one or more parts of the body. These secondary tumours may then grow, invade and damage nearby tissues, and spread again.

Some cancers are more serious than others, some are more easily treated than others, some have a better outlook (prognosis) than others.

So, cancer is not just one condition. In each case it is important to know exactly what type of cancer has developed, how large it has become, and whether it has spread. This will enable you to get reliable information on treatment options and outlook. See separate leaflet called 'Cancer - What are Cancer and Tumours' for further details about cancer in general.

What is kidney cancer?

There are several types of kidney cancer, but most cases are 'renal cell cancer'. This is sometimes called 'renal adenocarcinoma' or 'renal cell carcinoma' or 'hypernephroma'.

Renal cell cancer

This type of cancer develops from a cell in a kidney tubule which becomes cancerous. The cancer grows and forms into a tumour within the kidney. As the tumour grows:

• The affected kidney tends to become larger. In time the tumour may grow through the wall of the kidney and invade nearby tissues and organs such as the muscles around the spine, the liver, the nearby large blood vessels, etc.
• Some cells may break off into the lymph channels or bloodstream. The cancer may then spread to nearby lymph nodes or spread to other areas of the body (metastasise).

Renal cell cancers can be divided into several 'sub-types' by looking at certain features of the cells under a microscope. For example, most are 'clear cell' renal cell cancers, but some other types occur such as 'sarcomatoid', or 'granular' renal cell cancers. Knowing the sub-type of the cancer can be important as some respond to treatment better than others.

Other types of kidney cancer

Some rare types of cancer arise from other types of cell within the kidney. For example:

• Transitional cell (urothelial) cancers are cancers which arise from transitional cells. These are cells which line the renal pelvis, ureters and bladder. Transitional cell cancer is common in the bladder, but in some cases it develops in the renal pelvis.
• Wilms Tumour and Clear Cell Sarcoma of the kidney are types of kidney cancer which develop only in children.

What causes kidney cancer (renal cell cancer)?

A cancerous tumour starts from one abnormal cell. The exact reason why a cell becomes cancerous is unclear. It is thought that something damages or alters certain genes in the cell. This makes the cell abnormal and multiply 'out of control'. (See separate leaflet called 'Cancer - What Causes Cancer' for more details.)

In the UK, around 4,600 people are diagnosed with kidney cancer each year. Many people develop kidney cancer for no apparent reason. However, certain risk factors increase the chance that kidney cancer may develop. These include:

• Age. Most cases develop in people over the age of 60. It is uncommon in people under 50. It is also more common in men.
• Smoking. About a third of kidney cancers are thought to be caused by smoking. Some of the chemicals from tobacco get into the body and are passed out in urine. These chemicals in the urine can be carcinogenic (damaging) to kidney tubule cells.
• Other chemical carcinogens. Some workplace chemicals have been linked to an increased risk of kidney cancer. For example, asbestos, cadmium and some organic solvents.
• Obesity. Obesity is an established risk factor for kidney cancer. About a quarter of kidney cancer cases are due to being overweight.
• Kidney dialysis. People on long term dialysis have an increased risk.
• Hypertension. There is a greater risk in people who have high blood pressure.
• Genetic factors may play a role in some cases. (A 'faulty gene' which runs in some families may sometimes trigger kidney cancer. Also, people with some rare genetic disorders have a higher risk of developing kidney cancer. For example, von Hippel-Lindau syndrome, Birt-Hogg-Dube syndrome and tuberous sclerosus.)

What are the symptoms of kidney cancer?

Many people with kidney cancer have no symptoms at first, especially when the cancer is small. As the cancer develops, the following may occur.

Blood in urine

In many cases, the first symptom is to pass blood in the urine ('haematuria') which is usually painless. The blood in the urine may 'come and go' as the tumour bleeds from time to time. (There are many causes of blood in the urine apart from cancer such as bladder or kidney infections, inflammation of the kidney, kidney stones, etc. You should always report this symptom to your doctor, even if it goes, to clarify the cause of the bleeding.)

Other symptoms

Various other symptoms may occur, typically as the tumour becomes larger, and include:

• Pain or discomfort in the side or back of the abdomen ('loin pain').
• Fever (high temperatures) and sweats.
• A swelling in the area over a kidney.
• Anaemia, which can cause tiredness. You may also look pale.
• Some renal cell tumours produce abnormal amounts of certain hormones. This can lead to problems such as:
  • A high blood calcium level which can cause various symptoms such as increased thirst, feeling sick, tiredness, and constipation.
  • Too many red blood cells being made (polycythaemia).
  • High blood pressure.

As the cancer becomes larger you may feel generally unwell and lose weight. If the cancer spreads to other parts of the body, various other symptoms can develop.

How is kidney cancer diagnosed and assessed?

A doctor may suspect that you have kidney cancer from the symptoms and signs listed above, and then arrange tests to confirm the diagnosis. However, in developed countries, about half of kidney cancers are diagnosed before any symptoms develop. They are usually seen 'by chance' when a scan or other investigation is done for another reason.

Tests to confirm the diagnosis

An ultrasound scan of the kidney can usually detect a kidney cancer. This is often one of the first tests done if your doctor suspects that you may have kidney cancer. An ultrasound scan is a safe and painless test which uses sound waves to create images of organs and structures inside your body. See separate leaflet called 'Ultrasound Scan' for more details. A more sophisticated scan called a CT scan may be used if there is doubt about the diagnosis.

Assessing the extent and spread

If you are found to have a kidney cancer, then other tests are likely to be advised. These may include one or more of: a CT or MRI scan of the abdomen and chest, a chest X-ray, blood tests, and sometimes other tests. (See separate leaflets called 'CT Scan', 'MRI Scan', 'X-ray Test', 'Blood Test - Kidney Function' for more details.) This assessment is called 'staging' of the cancer.

The aim of staging is to find out:

• How much the tumour in the kidney has grown, and whether it has grown to the edge, or through the outer part of the kidney.
• Whether the cancer has spread to local lymph glands (nodes).
• Whether the cancer has spread to other areas of the body (metastasised).

Finding out the stage of the cancer helps doctors to advise on the best treatment options. It also gives a reasonable indication of outlook (prognosis). (See separate leaflet called 'Cancer - Staging and Grading Cancer' for more details.)

What are the treatments for kidney cancer (renal cell cancer)?

Treatment options which may be considered include surgery, radiotherapy, arterial embolisation and immunotherapy. (In general, chemotherapy does not work as well for renal cell cancer as for some other types of cancer. Therefore, it is not often used as a treatment.) The treatment advised for each case depends on various factors such as the stage of the cancer (how large the cancer is and whether it has spread), the exact sub-type or 'grade' of the cancer, and your general health.

You should have a full discussion with a specialist who knows your case. They will be able to give the pros and cons, likely success rate, possible side-effects, and other details about the various possible treatment options for your type of cancer.

You should also discuss with your specialist the aims of treatment. For example:

• In some cases, the treatment aims to cure the cancer. Some kidney cancers can be cured, particularly if they are treated in the early stages of the disease. (Doctors tend to use the word 'remission' rather than the word 'cured'. Remission means there is no evidence of cancer following treatment. If you are 'in remission', you may be cured. However, in some cases a cancer returns months or years later. This is why doctors are sometimes reluctant to use the word cured.)
• In some cases, the treatment aims to control the cancer. If a cure is not realistic, with treatment it is often possible to limit the growth or spread of the cancer so that it progresses less rapidly. This may keep you free of symptoms for some time.
• In some cases, treatment aims to ease symptoms. For example, if a cancer is advanced then you may require treatments such as painkillers or other treatments to help keep you free of pain or other symptoms. Some treatments may be used to reduce the size of a cancer which may ease symptoms such as pain.

Surgery

An operation to remove all (or sometimes part) of the affected kidney is the most common treatment. This is usually done as an open operation but it can also be done as a keyhole operation for some cases. If the cancer is at an early stage and not spread then surgery alone may be curative. If the cancer has spread to other parts of the body, surgery to remove the affected kidney may still be advised, often in addition to other treatments.

In some cases, surgery is done to remove a secondary kidney tumour which has spread to another part of the body. For example, some secondary tumours which develop in the liver or lung can be removed.

Radiotherapy

Radiotherapy is a treatment which uses high energy beams of radiation which are focused on cancerous tissue. This kills cancer cells, or stops cancer cells from multiplying. (See separate leaflet called 'Radiotherapy' for more details.) Radiotherapy may be advised in addition to surgery which aims to kill any cancerous cells which may have been left behind following an operation.

Radiotherapy may be used to treat the primary cancer instead of surgery if your general health is poor. It is also commonly used to treat kidney cancer which has spread to other sites such as secondary tumours which develop in a bone or the brain.

Arterial embolisation

This may be used instead of surgery (for example, if you are not well enough for surgery). The aim of this treatment is to block off the blood vessel (artery) which is supplying a kidney tumour with blood. To do this a catheter is inserted into a blood vessel in the groin. (A catheter is a long thin, flexible, hollow tube.) Using X-Ray pictures for guidance, the catheter is pushed up into the blood vessel in the affected kidney. When it is in the correct place a substance is injected down the catheter into the blood vessel to block the blood vessel. The tumour is then deprived of its blood supply and so dies.

Immunotherapy (sometimes called biological therapy)

This treatment uses drugs to stimulate the immune system to attack cancerous cells. Two drugs are commonly used to treat kidney cancer - interferon and aldesleukin (sometimes called interleukin 2).

Other immune therapies such as using 'vaccines' to stimulate your immune system to fight cancer cells and using monoclonal antibodies to attack cancer cells are being investigated as possible new treatments for kidney cancer.

There have recently been new targeted treatments introduced which are sunitinib and sorafenib. They are types of drugs called multikinase inhibitors which interfere with the growth of cancer cells. They also work by slowing the growth of new blood vessels within the tumour. They can shrink the cancer or slow its growth.

What is the prognosis (outlook)?

The outlook is best in those who are diagnosed when the cancer is confined within a kidney, has not spread, and who are otherwise in general good health. Surgical removal of an affected kidney in this situation gives a good chance of cure. However, many people with kidney cancer are diagnosed when the cancer has already spread. In this situation a cure is less likely. However, treatment can often slow down the progression of the cancer.

The response to treatment can also vary from case to case. This may be partly related to the exact sub-type or grade of the cancer. Some kidney cancers, even some which are advanced and have spread, respond much better to immunotherapy than others.

The treatment of cancer is a developing area of medicine. New treatments continue to be developed and the information on outlook above is very general. The specialist who knows your case can give more accurate information about your particular outlook, and how well your type and stage of cancer is likely to respond to treatment.

Further help and information

Kidney Cancer UK

PO Box 2473, Uttoxeter, Staffordshire, ST14 8WZ
Tel: 01889 565801 Web: www.kcuk.org
Provides information and support to kidney cancer patients and their carers.

Macmillan Cancer Support

3 Bath Place, Rivington Street, London, EC2A 3JR
Tel: 0808 800 1234 Web: www.macmillan.org.uk
Provides information and support to anyone affected by cancer.

Cancer Research UK

Web: www.cancerhelp.org.uk provides facts about cancer including treatment choices.

Other support groups

See www.patient.co.uk/selfhelp.asp for a list of support groups for cancer patients.