Came across this site while researching bisoprolol ( again!!) I have had to go back to my cardiologist because lately I have been feeling so exhausted I can hardly stay awake. I have been on this drug 10mg for 8 yrs and could put up with the cold extremeties, weight gain etc but now I have numbness in left hand ( doc said was nerve problem) runny nose wheeze and lethargy you wouldnt believe. Can this be right after so long on this? Cardiologist said it was too dangerous to stop drug and there is no alternative in my case.