I have dystonia. I take 2mg of trihexyphenidyl four times a day: at breakfast, lunch, evening meal and before bed. Taking it with or just after a meal reduces the slight waves of nausea that can occur throughout the day. Taking a dose at bedtime evens out the effect so that I don't have to wait for the morning dose to 'kick in'.

The drug can cause a dry mouth with 'sticky' saliva and slow the production of urine. This is another reason to spread the dose because when the effects wear off there is a real need to urinate. Regular fluid intake helps with the dry mouth and bladder problems.

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