Salivary Gland Disorders

oPatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.

See also separate article Salivary Gland Tumours.

Approximately 1.5 L/day of saliva is produced by three pairs of major salivary glands:

  • The parotid glands lie below the external auditory meatus, between the vertical ramus of the mandible and the mastoid process. The parotid duct crosses the masseter and opens via a small papilla on the buccal membrane opposite the crown of the second upper molar. The parotid gland has an intimate relationship with the facial nerve, which subdivides into its branches as it passes through the parotid.
  • The submandibular glands are walnut-sized paired structures, lying beneath and in front of the angle of the jaw, wrapping around the posterior edge of the mylohyoid muscle. Their ducts emerge to the floor of the mouth just lateral to the frenulum of the tongue.
  • The sublingual glands lie below the tongue and open through several ducts to the floor of the mouth.

There are also a large number (600-1,000) of minor salivary glands widely distributed throughout the oral mucosa, palate, uvula, floor of the mouth, posterior tongue, retromolar and peritonsillar area, pharynx, larynx and paranasal sinuses.

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Symptoms

  • Which of the glands is affected? Most commonly, it is the parotid. Conditions differentially affect the different salivary glands.
  • Is the swelling unilateral or bilateral?
  • Is the swelling painful? Pain may be referred to the ear or throat.
  • How long has the patient experienced symptoms? Has the mass increased in size since it was first noticed?
  • Are symptoms affected by eating?
  • Are there acute or ongoing systemic symptoms suggestive of infection, autoimmune disease, sarcoidosis or malignancy?
  • Consider current medical and dental history, medication and immunisation record.

Signs

  • The parotid glands:
    • Swellings of the parotid are apparent as a loss of the angle of the jaw. The accessory lobe may also cause a lump anterior to the ear. The deep lobe needs to be inspected and palpated through the mouth. Swelling can displace the ipsilateral tonsil. Try to differentiate between generalised swelling of the gland, which tends to be due to obstruction of the duct or inflammatory disease, or localised lumps, which are more likely to be tumours.
    • Ask the patient to clench their teeth to allow palpation of masseter. The anterior part of the parotid duct can be felt as it crosses the anterior border of the masseter muscle and occasionally a stone can be palpated in this part of the duct. Inspect the orifice of the duct in the mouth opposite the second upper molar by retracting the cheek with a spatula. Pressure on the body of the gland may lead to the extrusion of pus at the orifice in patients with parotitis.
    • Examine the facial nerve. Any facial weakness or asymmetry is highly suggestive of malignancy.
  • The submandibular glands:
    • Submandibular gland pathology usually involves swelling beneath and anterior to the angle of the jaw.
    • Inspect the orifices of the duct by asking the patient to lift their tongue to the roof of the mouth, noting the presence of inflammation or pus or indeed a visible impacted stone.
    • Examine bimanually with the index finger of one hand inside the mouth and fingers of the other hand over the outer surface of the lump in the neck. Under normal circumstances, the gland is not palpable but, if enlarged, can be felt 2-3 cm anterior to sternomastoid, below the horizontal ramus of the mandible.The gland has a rubbery consistency. The gland should not be fixed to the floor of the mouth or tongue. Check the course of the duct for a stone.
  • Sublingual gland pathology may cause swelling on the floor of the mouth.
  • Is this swelling a salivary gland? Differentiating a swollen parotid gland and cervical lymphadenopathy may be very difficult clinically. Usually it is possible to feel in front of lymph nodes but it is impossible to get in front of the parotid. Similarly, attempt to differentiate between a submandibular swelling and superior cervical lymph nodes which are deep to sternomastoid.
  • Are there systemic symptoms, eg malaise, pyrexia?
  • Are the eyes dry? Look for keratoconjunctivitis sicca and for other features of Sjögren's syndrome, such as xerostomia and lingual papillary atrophy.
  • Has tooth enamel been lost? (This can be associated with the recurrent vomiting from bulimia.)
  • Is there any regional lymphadenopathy?

Terminology:

  • Sialadenitis refers to inflammation of a salivary gland and may be acute or chronic, infective or autoimmune.
  • Sialolithiasis refers to stone-related disease within the ductal systems of a gland.
  • Sialectasis refers to the dilation of a duct due to stones or strictures.
  • Sialadenosis refers to non-neoplastic non-inflammatory swelling with acinar hypertrophy and ductal atrophy.

Causes of salivary gland swelling

In the parotid glands, these include: In the submandibular glands:
  • Stone in the salivary duct.
  • Benign and malignant tumours.
  • Sjögren's syndrome (less common).
In the minor salivary glands:
  • Mucoceles.
  • Benign and malignant tumours.
  • Mumps is the most common cause of salivary gland infection, although with widespread immunisation its incidence has fallen. It usually causes bilateral swelling of the parotid glands, although the other major salivary glands may also be affected in about 10% of infections. The swelling lasts 5 to 9 days accompanied by low-grade pyrexia and general malaise.
  • Other viruses that may acutely infect the salivary glands include Coxsackie virus, parainfluenza, influenza A, parvovirus B19 and herpes.
  • Acute bacterial infection of the major salivary glands occurs usually in debilitated or dehydrated patients. Comorbidity and/or medication may inhibit saliva production, increasing vulnerability. Prior to the advent of antibiotics and intravenous fluid rehydration, bacterial parotitis was often a pre-terminal event with a mortality of over 80%. Infection ascends from the oral cavity, most frequently Staphylococcus aureus.
  • Chronic bacterial infection may occur on a background of a gland previously damaged by stones, irradiation or autoimmune disease. Chronic infection destroys the glandular elements of the salivary glands and can impair the protective functions of saliva, leading to dental infections and disease. It consequently often first presents to a dentist.
  • Parotid swelling may be an initial presentation of HIV infection, and oral mucoceles and ranulas may also be a manifestation.[3]
  • Tuberculosis is a rare cause of parotitis and other salivary gland swelling but should be considered in the differential in someone who is immunosuppressed or from a high-risk population.[4]

Presentation

  • Swelling.
  • Dry mouth.
  • Abnormal or foul tastes associated with purulent discharge from salivary duct opening.
  • Mouth or facial pain, especially associated with eating.
  • Decreased mouth opening, difficulty talking.
  • Fever/systemically unwell.

Investigation

May include:

  • Blood tests - FBC, inflammatory markers, U&Es, blood culture, viral serology or salivary antibody testing, HIV test, as appropriate.
  • Pus swab for culture and sensitivities.
  • Sialography.
  • Ultrasound.
  • CT/MRI scan - often to exclude neoplasm.
  • Fine needle aspirate or incisional biopsy for histology or culture material.

Management

  • Mumps is a self-limiting condition without serious sequelae in most patients. Supportive treatment is appropriate. It remains a notifiable disease.
  • Acute suppurative infection is treated with antibiotics and incision and drainage if an abscess has developed.
  • With chronic infections, where duct obstruction is identified, stones or strictures can be removed, promoting saliva flow. Gland excision may sometimes be required where problems become recurrent.
  • Note: diseases of the salivary glands are rare in children (with the exception of acute parotitis usually due to mumps), so that any acute or chronic sialadenitis not responding to conservative treatment should be referred for specialist opinion.[5]

Complications

  • Mumps parotitis is rarely associated with sialectasia and recurrent sialadenitis.
  • Abscess formation with spread to the other deep neck spaces of the neck is the most concerning. Trismus may indicate parapharyngeal involvement. Ludwig's angina, where infection of the submental and sublingual spaces occurs, is rare but life-threatening.

Prevention

  • To prevent acute suppurative parotitis, consider risk factors, avoid anticholinergics and other drugs likely to disrupt saliva flow in the vulnerable and maintain good hydration and mouth care perioperatively and amongst critically ill patients. Mouth care is an important consideration in the care of the terminally ill.
  • A high uptake of measles, mumps and rubella (MMR) vaccine is essential to ensure herd immunity and prevent resurgence of mumps.
  • Calculi or stones can form in the major salivary glands and their ducts, causing obstruction of salivary outflow, typically with pain and swelling at meal times. This is most commonly seen in the submandibular gland and its duct, but may also be seen in the parotid glands. Obstruction is less common in the parotid gland, as its secretions are more watery and the duct is wider. Sublingual glands drain into 8-20 ducts so rarely obstruct.
  • Obstruction of minor salivary glands also occurs, resulting in cyst-like swellings in the lips and cheeks.
  • The cause of salivary gland stones is unknown. Stones are composed of mucus, cellular debris, calcium and magnesium phosphates.
  • Parotid gland obstructions are more usually due to stenosis of the opening of the duct rather than stones. This can sometimes be secondary to chronic trauma due to ill-fitting dentures.
  • Obstruction of a salivary duct causes inflammation and swelling of the gland.
  • If the obstruction is not relieved, the gland becomes damaged and may ultimately require complete excision.

Presentation

  • Usually, colicky postprandial swelling of the gland.
  • Symptoms typically relapse and remit.

Investigation

  • X-ray (AP, lateral, and oblique intraoral occlusal views) - most (70-80%) submandibular calculi are radio-opaque but most parotid stones are radiolucent.
  • Sialography provides information about the ductal system and obstruction is indicated by filling defects or strictures.
  • Ultrasound - stones appears as markedly hyperechoic lines or points with distal acoustic shadowing.

Management

  • Many stones will pass spontaneously so conservative treatment may consist of oral analgesics and antibiotics. Good hydration, warm compresses, and gland massage may assist the stone's passage.
  • Surgical management:
    • Proximal submandibular stones may be removed by dilating/incising Wharton's duct and a transoral approach.
    • Calculi in the submandibular duct may be removed by an incision in the floor of the mouth, whilst those in the substance of the gland may require gland excision.
    • However, increasingly, endoscopic and minimally invasive techniques or lithotripsy are being used with the aim of better preserving gland function.[6]

Prevention

Those who have had salivary calculi are more likely to produce them again. There are no evidence-based methods of prevention currently. Maintaining good hydration will aid saliva production and may reduce the risk of recurrence.

Treatment for sialadenosis is aimed at the underlying cause. The most common degenerative disease affecting the salivary glands is Sjögren's syndrome, an autoimmune condition.

  • It preferentially affects the parotid gland, but may also affect the submandibular and minor salivary glands. It usually also affects the lacrimal glands.
  • Sjögren's syndrome may be accompanied by other systemic diseases, such as rheumatoid arthritis, systemic lupus erythematosis or primary biliary sclerosis.
  • Sjögren's syndrome has a strong female predominance (9:1) and onset is typically in middle age.

Other causes of sialadenosis include:

Investigations

    Sjögren's syndrome shows a characteristic sialectasis and parenchymal destruction on sialogram and may be confirmed through many different tests including:
  • Biopsy of the labial salivary glands.
  • Autoantibodies - Sjögren's syndrome A (SS-A) and Sjögren's syndrome B (SS-B).
  • Rheumatoid factor (positive in about 90%).
  • Antinuclear antibodies.

If sarcoidosis is suspected, CXR may show bilateral hilar lymphadenopathy.

Management

In patients with Sjögren's syndrome, where the diagnosis is suspected, refer to rheumatology. Good dental care is essential to prevent caries. Parasympathetic drugs, such as pilocarpine, may be used for the treatment of hyposalivation and xerostomia. There is inadequate evidence currently to recommend local stimulants, lubricants and protectants, despite the widespread use of these products for symptomatic relief.[7] Gland excision is rarely indicated.

Complications

The risk of malignant non-Hodgkin's lymphoma is increased in primary Sjögren's syndrome.[8] It may be problematic to diagnose this in the context of persistent parotid swelling.[9]

Further reading & references

  1. Hviid A, Rubin S, Muhlemann K; Mumps. Lancet. 2008 Mar 15;371(9616):932-44.
  2. Chegar BE, Kelley RT; Wegener's granulomatosis presenting as unilateral parotid enlargement. Laryngoscope. 2004 Oct;114(10):1730-3.; Laryngoscope. 2004 Oct;114(10):1730-3.
  3. Syebele K, Butow KW; Oral mucoceles and ranulas may be part of initial manifestations of HIV AIDS Res Hum Retroviruses. 2010 Oct;26(10):1075-8. Epub 2010 Sep 23.
  4. Tauro LF, George C, Kamath A, et al; Primary tuberculosis of submandibular salivary gland. J Glob Infect Dis. 2011 Jan;3(1):82-5.
  5. Ellies M, Laskawi R; Diseases of the salivary glands in infants and adolescents. Head Face Med. 2010 Feb 15;6:1.
  6. Koch M, Zenk J, Iro H; Algorithms for treatment of salivary gland obstructions. Otolaryngol Clin North Am. 2009 Dec;42(6):1173-92, Table of Contents.
  7. von Bultzingslowen I, Sollecito TP, Fox PC, et al; Salivary dysfunction associated with systemic diseases: systematic review and Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103 Suppl:S57.e1-15.
  8. Zintzaras E, Voulgarelis M, Moutsopoulos HM; The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med. 2005 Nov 14;165(20):2337-44.
  9. Zenone T; Parotid gland non-Hodgkin lymphoma in primary Sjogren syndrome. Rheumatol Int. 2011 Mar 23.

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Chloe Borton
Current Version:
Peer Reviewer:
Dr Helen Huins
Document ID:
2745 (v24)
Last Checked:
28/09/2011
Next Review:
26/09/2016