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- There is a rising incidence and prevalence of diabetes mellitus. About 50% of people with diabetes mellitus are unaware of their condition. Approximately 25% of all patients with diabetes undergoing surgery are undiagnosed on admission to hospital.
- Patients with diabetes have a higher risk of cardiovascular disease. Patients with diabetes have a higher perioperative risk. They are more likely because of their disease to require surgery and those undergoing surgery are likely to be less well controlled and to have complications from their diabetes.
- Surgeons and anaesthetists operating on patients with diabetes should be familiar with the risks attached to having diabetes, and to the particular risks of the particular surgery and of anaesthesia in patients with diabetes.
Risks and complications of diabetes mellitus
Patients with diabetes mellitus are at risk of the complications of the disease. It is worth considering these in outline when considering how best to care for patients with diabetes undergoing surgery. See also the separate article on Diabetes Mellitus.
Perioperative risks and complications of diabetes mellitus
Interestingly, the risk of complications after coronary artery stenting may not be increased in diabetes. In another study of complications after renal transplantation there was no difference between recipients with diabetes and those without diabetes. It seems that there are other greater risk factors for poor outcome (including age of donor and recipient, time awaiting transplantation, etc).
Therefore, it is important in assessing risk of complications in patients with diabetes undergoing surgery to consider the specific type of surgery and anaesthetic technique. There is evidence for higher risk in those with diabetes undergoing surgery and, when such evidence is lacking, it may in part be testament to the relative safety of modern surgery and anaesthesia.
However, the following risks and observations are worth considering in patients with diabetes undergoing surgery:
- Myocardial infarction postoperatively (may be silent, has a greater mortality). There is an increased risk of postoperative acute myocardial infarction for people with diabetes. The myocardial infarction may be silent (no obvious symptoms) and has a greater overall mortality for people with diabetes.
- Patients with diabetes mellitus undergoing percutaneous coronary intervention (PCI) are at increased risk for adverse outcomes. It is not clear how this compares with surgery.
- Cardiac arrest as a consequence of autonomic neuropathy.
- Patients with diabetes and chronic kidney disease (diabetic nephropathy) have a worse outcome (complications and mortality) even accounting for the increased risk of associated conditions (hypertension, peripheral vascular disease).
- Stroke. This is consistent with the generally increased risk in diabetes mellitus, although again the surgical procedure and other risk factors for stroke (for example, smoking, anaesthetic technique) are important.
- Problems with lower limb ischaemia. This is consistent with high incidence of peripheral vascular disease.
- Heel pressure sores, particularly with peripheral neuropathy.
- Postoperative wound infection.
- Other infections such as chest and urinary infections are more common in those with diabetes. Tuberculosis can occur particularly in elderly patients with diabetes.
- Disruption and worsening of control of diabetes (for example, from the stress of surgery, lack of oral intake, postoperative vomiting, etc).
- Poor perioperative control of diabetes is associated with unfavourable outcomes in, for example, infra-inguinal bypass surgery.
- Poor intraoperative blood glucose control is associated with worse outcome after cardiac surgery in patients with diabetes.
- Diabetes mellitus is a risk factor for prolonged intensive care after cardiac surgery.
Pre-operative assessment of the patient with diabetes
Issues at the time of referral from primary care
- Ensure that the potential effects of diabetes and associated co-morbidities on the outcome of surgery are considered before referral for elective procedures.
- Ensure that the relevant medical information is communicated fully at the time of referral.
- Ensure that diabetes and comorbidities are optimally managed before the procedure.
- Provide the current HbA1c, blood pressure and weight measurements with details of relevant complications and medications in the referral letter.
- Optimise glycaemic control before referral if possible.
- Consider referral to the diabetes specialist team for advice if HbA1c is greater than 69 mmol/mol (8.5%). A high HbA1c is an indication for intensive blood glucose control but it may not be realistic to delay referral until the HbA1c has been repeated. Patients with hypoglycaemic unawareness should be referred to the diabetes specialist team irrespective of HbA1c.
- Optimise other diabetes related comorbidities.
- Provide written advice to patients undergoing investigative procedures requiring a period of starvation.
A careful pre-operative assessment should be done and may help improve outcome:
- To establish the history of the patient's diabetes and the state of their control of the diabetes.
- To look for complications of diabetes mellitus.
- To establish the safest method of anaesthesia and surgery.
It is apparent from a review of the risks of surgery associated with diabetes mellitus that the assessment and reduction of risk require an individual assessment of the particular patient and the surgery being undertaken.
History and examination
- Assessment of control should be made (records of HbA1c, etc).
- Cardiovascular disease:
- Evidence of angina, intermittent claudication should be sought.
- Examine for peripheral vascular disease.
- Examine for postural hypotension (systolic fall of >30 mm Hg on standing).
- Neurological disease:
- Symptoms of numbness, pain, paraesthesia, leg ulcers, transient ischaemic attacks, etc.
- Postural hypotension gives a late indication of autonomic neuropathy.
- An assessment of heart rate variability (HRV) during deep breathing is a much better way of detecting autonomic neuropathy earlier.
- Renal disease:
- Symptoms of polyuria may reflect glycosuria or chronic kidney disease.
- Anaemia and hypertension should be detected as possible associated conditions.
- Skin, feet and general examination:
- The skin should be examined for sepsis.
- Pressure areas (heels, buttocks, etc) should be examined for sores.
- Blood glucose (serial readings) and HbA1c (more relevant for long-term control). Blood glucose control must be optimised before surgery if possible.
- ECG (with Valsalva manoeuvre) to assess for ischaemic and other cardiovascular disease.
- U&Es (assess for renal complications) and estimated glomerular filtration rate (eGFR).
- Urine analysis. Ketones (poor control), protein (possible renal complications) and bacteriology (for infection).
- CXR. This may be indicated to screen for pulmonary infection, including tuberculosis.
Choice of anaesthetic
- Local or general anaesthesia can be used.
- Local anaesthesia:
- Reduces the stress response.
- Hypoglycaemia readily detectable with the patient awake.
- Postoperative nausea reduced.
- Easy postoperative control of diabetes.
- General anaesthesia. Consideration should be given to:
- The presence of cardiovascular and renal disease.
- Prevention of intraoperative hypoglycaemia.
- Autonomic neuropathy (it can mask hypoglycaemia and may exacerbate respiratory depression with opioids).
- Avoidance of hypotension (increased risk of spinal cord infarction).
- Protection of pressure areas.
Guidance on perioperative management for people with diabetes is included in the Joint British Diabetes Societies Inpatient Care Group guidance 'Management of adults with diabetes undergoing surgery and elective procedures: improving standards'.
In general, emergency or non-elective cases must have blood glucose controlled with insulin, glucose and potassium infusions as above with special attention being given to rehydration before surgery.
- Diabetic ketoacidosis. This can present as abdominal pain and vomiting, with the vomiting usually preceding the pain (unlike in the acute abdomen when pain usually precedes vomiting). If diabetic ketoacidosis does not respond to treatment, it should be remembered that the acute abdomen may have triggered diabetic ketoacidosis.
- Anaesthesia and surgery in diabetic ketoacidosis are hazardous but occasionally required (eg, for perforated diverticular abscess). For example, there is a risk of cerebral oedema (resulting from swings in serum osmolarity) and the effects of acidosis on ventilation can cause problems.
- Hyperosmolar non-ketotic diabetic coma. These patients rarely require surgery but, if required, it is high-risk. Heparinisation is usually required.
- Lactic acidosis should be suspected when there is acidosis but no ketosis. It can be caused by the effects of biguanides but occurs also in septicaemia, pancreatitis, liver failure and chronic kidney disease.
Further reading & references
- Diabetes; NICE
- International Diabetes Federation
- Lanzer P, Weser R, Prettin C; Carotid-artery stenting in a high-risk patient population--single centre, single operator results. Clin Res Cardiol. 2006 Jan;95(1):4-12.
- Bittar J, Cepeda P, de la Fuente J, et al; Renal transplantation in diabetic patients. Transplant Proc. 2006 Apr;38(3):895-8.
- Gaston RS, Deierhoi MH, Young CJ, et al; "High-risk" renal transplantation: evolving definitions at a single center. Clin Transpl. 2004;:121-6.
- Schipper ON, Jiang JJ, Chen L, et al; Effect of Diabetes Mellitus on Perioperative Complications and Hospital Outcomes After Ankle Arthrodesis and Total Ankle Arthroplasty. Foot Ankle Int. 2014 Nov 20. pii: 1071100714555569.
- Weber FD, Schneider H, Wiemer M, et al; Sirolimus eluting stent (Cyphertrade mark) in patients with diabetes mellitus: results from the German Cypher Stent Registry. Clin Res Cardiol. 2008 Feb;97(2):105-9. Epub 2007 Dec 6.
- De Servi S, Guastoni C, Mariani M, et al; Chronic renal failure in acute coronary syndromes. G Ital Cardiol (Rome). 2006 Apr;7(4 Suppl 1):30S-35S.
- Sigala F, Georgopoulos S, Langer S, et al; Outcome of infrainguinal revascularization for critical limb ischemia in diabetics with end stage renal disease. Vasa. 2006 Feb;35(1):15-20.
- Rockman CB, Saltzberg SS, Maldonado TS, et al; The safety of carotid endarterectomy in diabetic patients: clinical predictors of adverse outcome. J Vasc Surg. 2005 Nov;42(5):878-83.
- Diehm C, Lawall H; Diabetes, heart surgery and the peripheral arteries. Clin Res Cardiol. 2006 Jan;95(Supplement 1):i63-i69.
- Antibiotic prophylaxis in surgery, SIGN Guidelines (Apr 2014)
- Malmstedt J, Wahlberg E, Jorneskog G, et al; Influence of perioperative blood glucose levels on outcome after infrainguinal bypass surgery in patients with diabetes. Br J Surg. 2006 Jun 16.
- Ouattara A, Lecomte P, Le Manach Y, et al; Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients. Anesthesiology. 2005 Oct;103(4):687-94.
- Gandhi GY, Nuttall GA, Abel MD, et al; Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients. Mayo Clin Proc. 2005 Jul;80(7):862-6.
- Ghotkar SV, Grayson AD, Fabri BM, et al; Preoperative calculation of risk for prolonged intensive care unit stay following coronary artery bypass grafting. J Cardiothorac Surg. 2006 May 31;1(1):14.
- Joint British Diabetes Societies Inpatient Care Group; Management of adults with diabetes undergoing surgery and elective procedures: improving standards. April 2011.
- Schmiesing CA, Brodsky JB; The preoperative anesthesia evaluation. Thorac Surg Clin. 2005 May;15(2):305-15.
- Huang CJ, Kuok CH, Kuo TB, et al; Pre-operative measurement of heart rate variability predicts hypotension during general anesthesia. Acta Anaesthesiol Scand. 2006 May;50(5):542-8.
- Tamai D, Awad AA, Chaudhry HJ, et al; Optimizing the medical management of diabetic patients undergoing surgery. Conn Med. 2006 Nov-Dec;70(10):621-30.
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Dr Richard Draper
Dr Colin Tidy
Dr Adrian Bonsall