Post-inflammatory Hypopigmentation of Skin

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This presents as poorly defined whitening of the skin, which is irregular in outline. Often the loss of pigment is partial rather than complete.[1] The surface is usually normal but scaling may be present if the underlying cause is scaly (such as eczema or psoriasis).[2] 

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Partial loss of pigment may follow any inflammatory skin reaction but this is most noticeable in those with dark skin. Scarring conditions such as thermal burns, discoid lupus and lichen planus will cause white atrophic hypopigmented areas.[1] Postinflammatory hypopigmentation is a recognised hazard of laser therapy.[3] 

The differential diagnosis includes:

  • Vitiligo - this is normally well defined, geographic in shape and there is complete loss of pigment.
  • Pityriasis versicolor - this is made up of coalescing oval/round macules which may be slightly scaly.
  • Pityriasis alba - this is seen on the face of children as slightly scaly, poorly defined macules and patches. It is common in children with dark skin but is seen in Caucasians in the summer. It is assumed to be a mild form of eczema with hypopigmentation.
  • Hypopigmented mycosis fungoides - a slow progressive cutaneous T-cell lymphoma.[6] 
  • Naevus depigmentosus - a congenital nonprogressive hypopigmented macule or patch that is stable in its relative size and distribution throughout life.[7] 
  • Nummular eczema.[8]
  • Idiopathic guttate hypomelanosis - this causes widespread hypopigmented macules on the arms and legs of middle-aged women and elderly men and women.[9] 

It may be possible to make the diagnosis on clinical grounds based on the appearance, size, site and distribution of lesions, the age and the sex of the patient. However, skin scraping for mycology and/or biopsy for histopathology may be necessary. Laser scanning microscopy may be helpful in diagnosing hypopigmentation disorders and may offer an alternative to invasive methods.[10] 

Treatment of the underlying condition is the mainstay of management. With sun exposure the white areas should eventually repigment unless scarring has occurred. 

Depigmentation often resolves spontaneously after weeks or months but may persist on occasion.[11] 

Referral may be needed in cases of diagnostic difficulty.

Further reading & references

  1. Pigmentation disorders; DermNet NZ
  2. Psoriasis; Dermnet NZ, 2013
  3. Choi CW, Kim HJ, Lee HJ, et al; Treatment of nevus of Ota using low fluence Q-switched Nd:YAG laser. Int J Dermatol. 2013 Jul 8. doi: 10.1111/ijd.12085.
  4. Tey HL; A practical classification of childhood hypopigmentation disorders. Acta Derm Venereol. 2010;90(1):6-11. doi: 10.2340/00015555-0794.
  5. Neynaber S, Kirschner C, Kamann S, et al; Progressive macular hypomelanosis: a rarely diagnosed hypopigmentation in Caucasians. Dermatol Res Pract. 2009;2009:607682. doi: 10.1155/2009/607682. Epub 2009 Jun 1.
  6. Zhang JA, Yu JB; Hypopigmented mycosis fungoides in a chinese woman. Indian J Dermatol. 2013 Mar;58(2):161. doi: 10.4103/0019-5154.108093.
  7. Lee DJ, Kang HY; Is spontaneous disappearance of nevus depigmentosus possible? Ann Dermatol. 2012 Feb;24(1):109-11. doi: 10.5021/ad.2012.24.1.109. Epub 2012 Feb 2.
  8. Nummular Eczema; American Osteopathic College of Dermatology
  9. Kim SK, Kim EH, Kang HY, et al; Comprehensive understanding of idiopathic guttate hypomelanosis: clinical and histopathological correlation. Int J Dermatol. 2010 Feb;49(2):162-6. doi: 10.1111/j.1365-4632.2009.04209.x.
  10. Xiang W, Xu A, Xu J, et al; In vivo confocal laser scanning microscopy of hypopigmented macules: a preliminary comparison of confocal images in vitiligo, nevus depigmentosus and postinflammatory hypopigmentation. Lasers Med Sci. 2010 Jul;25(4):551-8. doi: 10.1007/s10103-010-0764-2. Epub 2010 Feb 24.
  11. Vachiramon V, Thadanipon K; Postinflammatory hypopigmentation. Clin Exp Dermatol. 2011 Oct;36(7):708-14. doi: 10.1111/j.1365-2230.2011.04088.x. Epub 2011 Jun 14.

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Laurence Knott
Current Version:
Peer Reviewer:
Prof Cathy Jackson
Last Checked:
02/08/2013
Document ID:
4052 (v22)
© EMIS