Listeriosis

oPatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.

Listeria spp. are Gram-positive non-sporing rods which are ubiquitous in the environment and found worldwide.[1] Listeria monocytogenes is the major pathogen, although occasional human infections with Listeria ivanovii and Listeria seeligeri have been reported.

Listeria spp. are not very pathogenic to healthy adults, who are likely to experience only mild infection, causing flu-like symptoms or gastroenteritis. However, listeriosis can occasionally lead to septicaemia or meningitis. Pregnant women, the elderly and people with weakened immune systems (including those treated with oral corticosteroids) are more susceptible to listeriosis. Unborn babies and neonates are at particular risk of severe illness and listeriosis in pregnancy can cause miscarriage, premature delivery or severe illness in a newborn child.[1]

  • The total number of cases of L. monocytogenes reported to the Health Protection Agency in England and Wales in 2011 was 147 (120 non-pregnancy-related and 27 pregnancy-related).[1]
  • L. monocytogenes is common in wild animals, domesticated animals and in soil and water. It causes disease in many animals and is a common cause of miscarriage and stillbirth in domestic animals.
  • Infection may be foodborne or from direct contact with animals (particularly during calving, lambing, and postmortem examinations). Spread from mother to fetus may occur in utero or during birth.
  • Listeria spp. have a peculiar property of being able to grow at low temperatures, ie on contaminated refrigerated food, and are an important foodborne pathogen. Soft cheeses and meat-based pâté have been implicated in outbreaks.
  • The bacterium has been isolated from a range of raw foods, including vegetables, uncooked meats and processed foods. Eating cooked food that has then been refrigerated and recooked is a particular risk for causing infection. Usually killed by cooking or pasteurisation, it can survive some forms of pasteurisation, particularly if the bacterial count is high.
  • L. monocytogenes is often carried in the human bowel (1-10% carrier rate).

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  • Incubation time can vary from 3-70 days in adults, and a few days to a few weeks in infants.[1]
  • Infection in healthy children and adults, including maternal infections, may be asymptomatic.
  • L. monocytogenes most often causes an influenza-like illness. More severe infection in risk groups may lead to stillbirth, septicaemia or meningoencephalitis.
  • Infection of a pregnant woman early in pregnancy often leads to miscarriage. Maternal infection during pregnancy may be asymptomatic or include fever, myalgia, headache, sore throat, cough, vomiting, diarrhoea and vaginitis.
  • The organism may be transmitted across the placenta. Infections in late pregnancy may lead to stillbirth, or death of the infant within a few hours of birth. About half of infected infants at or near term will die.
  • Infants with listeriosis may present in the first few days of life with poor feeding, lethargy, jaundice, vomiting, respiratory distress, skin rash and shock. Infants usually have pneumonia. The death rate is very high.
  • Infants presenting at age 5 days or older often present with meningitis.
  • In adults, the disease is usually asymptomatic or causes mild illness such as an influenza-type illness, conjunctivitis, skin lesions or gastroenteritis. More severe infection, particularly in immunocompromised adults, may cause meningitis, pneumonia, septicaemia and endocarditis.
  • Vets and farmers may develop cutaneous listeriosis, presenting as papular or pustular lesions on the arms or hands, following contact with infected animals.
  • Cultures of amniotic fluid, blood, urine and cerebrospinal fluid (CSF); stool cultures are not sensitive or specific.
  • Serological testing is unreliable.
  • CXR.
  • MRI is superior to CT scan for demonstrating central nervous system disease, especially in the brainstem.
  • Transoesophageal echocardiography should be performed if endocarditis is suspected.
  • Most cases of non-invasive listeriosis in healthy adults and older children only require symptomatic treatment, e.g. treatment for gastroenteritis.
  • Amoxicillin and ampicillin are used to treat more severe infection and infection in pregnant women.[3]
  • Longer courses are required for immunocompromised patients.[2]
  • Invasive listeriosis (meningitis or septicaemia): intravenous amoxicillin/ampicillin plus gentamicin for 21 days (gentamicin may be stopped after 7 days).[4] Meningoencephalitis and endocarditis require a longer duration of treatment.[2]
  • Whenever listeriosis is a clinical possibility, eg acute pyogenic meningitis, and the organism is unknown, intravenous amoxicillin/ampicillin should always be part of the regimen.[5]
  • Listeria spp. are resistant to cephalosporins.
  • Gentamicin should be avoided in pregnancy and amoxicillin/ampicillin is then used alone.
  • Erythromycin is used instead of amoxicillin/ampicillin if the patient is allergic to penicillin.
  • Intravenous co-trimoxazole is the best second-line treatment for listerial meningoencephalitis.[4]

Infants who survive listeriosis may suffer long-term neurological damage and delayed development.

  • Most cases of listeriosis in heathy adults and children are mild and of short duration with complete recovery.
  • Infection of the fetus with L. monocytogenes results in a poor outcome with approximately a 50% death rate.
  • The late-onset infant form also has a high death rate.
  • There is a 20-50% mortality from septicaemia and meningoencephalitis, with significant long-term morbidity in survivors.
  • Pregnant women should avoid contact with wild and domestic animals.
  • Pregnant women should avoid consumption of soft cheeses, delicatessen meats, pâtés, spreads, refrigerated smoked seafood, and cold salads from salad bars.
  • Non-pasteurised soft cheeses have also been implicated in outbreaks of listeriosis.
  • Food should always be adequately cooked, or thoroughly reheated.

Further reading & references

  1. Listeria, Health Protection Agency
  2. Weinstein KB, Listeria Monocytogenes, Medscape, Jan 2012
  3. Janakiraman V; Listeriosis in pregnancy: diagnosis, treatment, and prevention. Rev Obstet Gynecol. 2008 Fall;1(4):179-85.
  4. British National Formulary; 63rd Edition (Mar 2012) British Medical Association and Royal Pharmaceutical Society of Great Britain, London
  5. Safdar A, Armstrong D; Antimicrobial activities against 84 Listeria monocytogenes isolates from patients with systemic listeriosis at a comprehensive cancer center (1955-1997). J Clin Microbiol. 2003 Jan;41(1):483-5.

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Colin Tidy
Current Version:
Peer Reviewer:
Dr Adrian Bonsall
Last Checked:
05/09/2012
Document ID:
797 (v23)
© EMIS