Mycetoma (Madura Foot)

oPatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.

Synonym: Madura foot

Mycetoma (named because of the tumour-like mass it forms) is a chronic granulomatous disease characterised by localised infection of subcutaneous tissues by actinomycetes or fungi. The inflammatory response can extend to the underlying bone.[1] Mycetoma was described first in the mid-1800s and was initially called Madura foot.[2]

  • The infection can be caused by true fungi (eumycetoma) in 40%, or filamentous bacteria (actinomycetoma) in 60%.
  • Actinomycetoma may be due to Actinomadura madurae, Actinomadura pelletieri, Streptomyces somaliensis, Nocardia spp.
  • Eumycetoma is often due to Pseudallescheria boydii (Scedosporium apiospermum), Madurella mycetomatis.
  • Infection enters through sites of local trauma, eg cut or splinter, causing a granulomatous reaction. Spread occurs through skin facial planes and can involve the bone. It most commonly involves the foot but can involve the hands, back or shoulders.
  • The disease is endemic in the tropics and subtropics and is named after the region of India where it was first described in 1842. It occurs in what has been described as 'the mycetoma belt' between the latitudes of 15° South and 30° North and is endemic in arid areas.[3]
  • There are a series of case reports from African countries including Sudan.
  • Although currently uncommon in temperate regions, it does occur in the southern USA, and cases are found in the homeless, and in AIDS sufferers.
  • The incidence of mycetoma is likely to rise in temperate regions due to increases in worldwide travel and, since mycoses are not notifiable, the incidence in the UK is unknown.

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Risk factors

  • Mycetoma typically presents in agricultural workers (hands, shoulders and back - from carrying contaminated vegetation and other burdens), or in individuals who walk barefoot in dry, dusty conditions.
  • Minor trauma allows pathogens from the soil to enter the skin.
  • Following the initial injury, the disease typically follows a slow chronic course over many years with painless swelling and intermittent discharge of pus.
  • There may be a deep itching sensation.
  • Pain may occur due to secondary bacterial infection or bone invasion.
  • After some years, massive swelling of the area occurs, with induration, skin rupture, and sinus tract formation. As the infection spreads, old sinuses close and new ones open.
  • The exudates are typically granular.
  • Microscopy and culture of exudates, and skin biopsy for pathology are necessary to identify the causative organism.
  • Serology can be helpful with diagnosis or follow-up care during medical treatment.
  • DNA sequencing has been used for identification in difficult cases.[4]
  • Plain X-rays are used to assess for evidence of bone involvement.[5]
  • CT scan may be more sensitive in the early stages.
    MRI scans can provide a better assessment of the degree of bone and soft tissue involvement; and may be useful in evaluating the differential diagnosis of the swelling.

Actinomycetomas usually respond better to medical treatment than eumycetomas, which are often difficult to treat. Bone involvement complicates clinical management, often leaving surgical amputation as the only treatment option.[6]

  • Due to the slow, relatively pain-free progression of the disease, mycetoma is often at an advanced stage when diagnosed.
  • Surgical debridement, followed by prolonged appropriate antibiotic therapy for several months is required for actinomycetoma.[7] Combination therapy with trimethoprim-sulfamethoxazole, dapsone and streptomycin has been used. Rifampin has been used in resistant cases.[2]
  • Eumycetomas are only partially responsive to antifungal therapy but can be treated by surgery, due to their normally well circumscribed nature. Surgery in combination with azole treatment is the recommended regime for small eumycetoma lesions in the extremities.[6] Madurella mycetomatis may respond to ketoconazole, P. boydii (S. apiospermum) may respond to itraconazole. Other agents of eumycetoma may respond intermittently to itraconazole[8] or amphotericin B.
  • The disease causes disfigurement but is rarely fatal.
  • In advanced cases, deformities or ankylosis may occur.
  • Chronic neglected infection may necessitate amputation.
  • Immunocompromised patients may develop invasive infection.
  • Lymphatic obstruction and fibrosis may cause lymphoedema.
  • Complications may result from toxicity due to prolonged antimicrobial or antifungal therapy.
  • Actinomycetoma can be cured with the appropriate antibiotic therapy but eumycetoma has a high rate of recurrence and can require amputation.
  • A high incidence of secondary bacterial infection in mycetoma lesions has been reported.[9] This can cause increased pain and disability as well as septicaemia, which may be fatal if untreated.

Further reading & references

  1. Lichon V, Khachemoune A; Mycetoma : a review. Am J Clin Dermatol. 2006;7(5):315-21.
  2. Ania BJ et al; Mycetoma, eMedicine, Aug 2008
  3. Fahal AH; Mycetoma: a thorn in the flesh. Trans R Soc Trop Med Hyg. 2004 Jan;98(1):3-11.
  4. Yera H, Bougnoux ME, Jeanrot C, et al; Mycetoma of the foot caused by Fusarium solani: identification of the etiologic agent by DNA sequencing. J Clin Microbiol. 2003 Apr;41(4):1805-8.
  5. Corr P; Clinics in diagnostic imaging (26). Madura foot (or mycetoma). Singapore Med J. 1997 Jun;38(6):268-9.
  6. Ahmed AA, van de Sande WW, Fahal A, et al; Management of mycetoma: major challenge in tropical mycoses with limited international recognition. Curr Opin Infect Dis. 2007 Apr;20(2):146-51.
  7. Davis JD, Stone PA, McGarry JJ; Recurrent mycetoma of the foot. J Foot Ankle Surg. 1999 Jan-Feb;38(1):55-60.
  8. Lexier R, Walmsley SL; Successful treatment of Madura foot caused by Pseudallescheria boydii with Escherichia coli superinfection: a case report. Can J Surg. 1999 Aug;42(4):307-9.
  9. Ahmed AO, Abugroun ES; Unexpected high prevalence of secondary bacterial infection in patients with mycetoma. J Clin Microbiol. 1998 Mar;36(3):850-1.

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Colin Tidy
Current Version:
Last Checked:
21/01/2011
Document ID:
1102 (v22)
© EMIS