Brain tumours are the most common site for solid tumours in childhood. A small peak in incidence of brain tumours in early childhood drops to a minimum in teenage years. Most childhood brain tumours (70-80%) are infratentorial (glial tumours, medulloblastoma) or in the midline (germ cell tumours, craniopharyngioma). Glial tumours in children are more frequently low-grade.
Brain tumours generally have a better outcome in children than adults but children with brain tumours are frequently unwell for months prior to diagnosis and a prolonged period between symptom onset and diagnosis is associated with increased morbidity.
- Brain and central nervous system (CNS) tumours (malignant and non-malignant) are the second most common group of cancers in children, accounting for a quarter of all childhood cancers. In the UK, brain tumours occur in about 5 per 100,000 of children between the ages of 0-9 years.
- The largest subgroup is astrocytoma (43% of all brain and CNS tumours in children). Astrocytomas are diagnosed throughout childhood. 76% of astrocytomas are diagnosed as 'low-grade' and 15% as 'high-grade'.
- The second most common subgroup is the intracranial and intraspinal embryonal tumours (19% of all childhood brain and CNS tumours). Most of these are primitive neuroectodermal tumours (PNETs) and about 73% are medulloblastomas. PNETs occur most frequently in younger children.
- About 10% of childhood brain and CNS tumours are ependymoma and choroid plexus tumours. The incidence is highest in one-year-old children.
- The underlying cause of brain tumours is unknown. However, some tumours are more common with certain illnesses, eg astrocytomas are seen with increased frequency in neurofibromatosis and haemangioblastomas are more prevalent in patients with von Hippel-Lindau disease. This suggests a genetic link and mutations in several genes, including the retinoblastoma gene (RB1), neurofibromatosis genes (NF1 and NF2) and tuberous sclerosis gene (TSC1) - which function as tumour suppressor genes have been proposed. However, most cases of brain tumours are sporadic.
- Previous cranial irradiation also increases the risk of brain tumours, eg meningeal leukaemia. A Canadian study looked at the correlation between early infections and brain tumours in 272 children and found an increased proportion of this group had a positive history of infections, eg use of antibiotics during gestation, removal of tonsils or adenoids. However, further observational-based studies are required to draw any firm conclusions from this data.
Types of brain tumours
- Gliomas (gliomas are graded according to whether slow-growing (low-grade) or fast-growing (high-grade); grade 1 is the slowest-growing type and grade 4 is the fastest-growing).
- Astrocytic tumour: low-grade astrocytoma, anaplastic astrocytoma, glioblastoma multiforme.
- Oligodendroglioma: benign or anaplastic.
- Ependymoma: benign or anaplastic.
- Mixed glioma: astrocytoma and oligodendroglioma.
- Ganglioglioma: benign or anaplastic.
- Choroid plexus tumour: papilloma or carcinoma.
- Primitive neuroectodermal tumours: supratentorial primitive neuroectodermal tumours, medulloblastoma, pineoblastoma.
- Congenital: teratoma, craniopharyngioma.
- Pineal tumours: germinoma, endodermal sinus tumour, embryonal cell carcinoma, choriocarcinoma, pineocytoma or pineoblastoma.
- Very rare tumours: primary CNS lymphoma.
- Benign tumours (more common in adults): meningioma, acoustic neuroma, pituitary tumour.
Localisation and frequency of childhood brain tumours
- Hemispheric: glioma 37% (low-grade 23%, high-grade 11%, others 3%).
- Midline: chiasmal gliomas 4%, craniopharyngiomas 8%, pineal region tumours 2%.
- Posterior fossa: brainstem gliomas 15%, medulloblastomas 15%, ependymomas 4%, cerebellar astrocytomas 15%.
One recent meta-analysis found that the most frequent symptoms and signs at diagnosis are:
- Intracranial tumours:
- Children aged under 4 years with intracranial tumours:
- Children with an intracranial tumour and neurofibromatosis:
- Posterior fossa tumours:
- Nausea and vomiting, headache, abnormal gait and co-ordination, and papilloedema.
- The presentation of infratentorial tumours relates to blockage of the CSF flow, leading to hydrocephalus. Common signs and symptoms include morning headache, vomiting (may be the only symptom of an ependymoma), ataxic gait with unsteadiness, double vision and papilloedema.
- Brainstem tumours may also present with facial or ocular muscle palsies and hemiparesis.
- Supratentorial tumours:
- Unspecified symptoms and signs of raised intracranial pressure, seizures and papilloedema.
- Central brain tumours:
- Headache, abnormal eye movements, squint, and nausea and vomiting.
- Brainstem tumours:
- Abnormal gait and co-ordination, cranial nerve palsies, pyramidal signs, headache and squint.
- Other neurological features related to tumour location (eg frontal lobe tumours are associated with personality change and occipital lobe tumours are associated with visual deficits). Other symptoms relating to type or location of brain tumour include:
- Other features included weight loss, growth failure and precocious puberty. Symptoms of raised intracranial pressure were absent in more than half of children with brain tumours.
- MRI is the preferred modality of imaging, as it provides better images and there is no radiation involved. However, compared to CT scanning it takes longer and the child may need sedating, as they are required to remain still for the entire procedure. Usually contrast is also given to detect areas of damage to the blood brain barrier and highlight the extent of oedema around the tumour. MRI will provide detailed information regarding the tumour size, location, extent, surrounding oedema and presence of hydrocephalus.
- Biopsy - often excision biopsy of surgically removed tumour.
- Other investigations may include hearing tests and pituitary function tests.
- CSF analysis can reveal increased levels of human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP) in pineal tumours and raised serial polyamines in recurrence of medulloblastoma before radiological detectable recurrence. However, lumbar puncture and CSF evaluation generally have little to add in the diagnosis of childhood brain tumours.
There are very few randomised controlled trials looking at the effectiveness of surgical resection, radiotherapy and chemotherapy. Management also includes treatment of complications (eg raised intracranial pressure, hydrocephalus, seizures, pituitary hormone deficiencies), support for the child and their family and addressing any associated psychological and educational difficulties.
- Surgical resection is very important and recent data suggest that complete total resection, especially of gliomas, should always be the aim and is associated with improved survival in children.
- However, complete resection of the tumour is very rarely achievable as the margins of most tumours are indistinct. This means that during surgical resection it becomes difficult to determine whether abnormal or normal tissue is being resected. Resection also allows for a biopsy to be taken which in some types of brain tumour alters therapy.
- Biopsy may be performed beforehand and usually direct open biopsy is preferred at the time of surgery although, for basal ganglia and brain stem lesions, stereotactic biopsies are taken. Preoperatively, children may be given phenytoin to prevent seizures and corticosteroids to reduce brain oedema.
- Hydrocephalus is common postoperatively and therefore at the time of surgery an external ventricular drain or ventriculoperitoneal shunt is inserted which will be removed a few days later once the CSF clears.
- Very young children (under the age of 2 years) require radical resection as radiotherapy is delayed until they are older, as it will damage local normal tissue which is still developing. This is usually followed by chemotherapy.
- This is provided in low doses and to very localised areas to avoid damage to surrounding normal brain tissue. There are various techniques that can be employed, eg gamma knife (used for slow-growing lesions) and interstitial seeds which are implanted during surgery.
- There are various chemotherapy regimens in use and they usually involve vincristine. In the rare primary CNS lymphoma, chemotherapy alone has been used with good outcomes.
- In low-grade gliomas, if residual disease remains after excision then chemotherapy has been used. Newer chemotherapeutic regimens are being used including vincristine, etoposide, cyclophosphamide and 5-fluorouracil.
Follow-up after treatment
- Intellectual decline - a recent study of 120 young patients with primary brain tumours showed a decline in sustained attention span and reaction times. This appeared to be caused by multiple factors including local tumour effects, surgery and radiotherapy. More recently, guidance on detecting and monitoring cognitive decline have been proposed.
- Growth hormone deficiency is common (thyroid hormone deficiency is less common).
- Neurological handicap may occur and be permanent.
- Increased risk of a second brain tumour 10-20 years down the line due to irradiation (eg developing meningioma or sarcoma) - risk is increased if the brain is irradiated at a very young age.
- Reduced bone mineral density of multifactorial origin.
- Cavernomas presenting as haemorrhagic lesions are increasingly being associated with CNS irradiation.
- Resection of the tumour may resolve seizures and headaches. The surgical mortality is 1% for a paediatric craniotomy. The morbidity is higher and depends on the child's condition preoperatively. Figures such as, 5-10% for gliomas and 20-30% for basal ganglia gliomas have been reported.
- Tumours of the brain and central nervous system are the most common cause of deaths from cancer in childhood, accounting for around a third of all cancer deaths in children.
- A recent meta-analysis suggests that prenatal supplementation with multivitamins, including folic acid, is associated with a reduced incidence of brain tumours and leukaemia. However, this evidence still needs further validation.
Further reading & references
- Brain and other central nervous system tumours - UK incidence statistics, Cancer Research UK
- Wilne S, Koller K, Collier J, et al; The diagnosis of brain tumours in children: a guideline to assist healthcare Arch Dis Child. 2010 Jul;95(7):534-9. Epub 2010 Apr 6.
- Childhood cancer incidence statistics, Cancer Research UK, Oct 2005
- Rice JM; Inducible and transmissible genetic events and pediatric tumors of the nervous system. J Radiat Res (Tokyo). 2006;47 Suppl B:B1-B11.
- Bondy ML, Scheurer ME, Malmer B, et al; Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 2008 Oct 1;113(7 Suppl):1953-68.
- Shaw AK, Li P, Infante-Rivard C; Early infection and risk of childhood brain tumors (Canada). Cancer Causes Control. 2006 Dec;17(10):1267-74.
- Albright AL; Pediatric brain tumors. CA Cancer J Clin. 1993 Sep-Oct;43(5):272-88.
- Wilne S, Collier J, Kennedy C, et al; Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncol. 2007 Aug;8(8):685-95.
- Schobitz E, Qureshi F, Lewis D; Pediatric headaches in the emergency department. Curr Pain Headache Rep. 2006 Oct;10(5):391-6.
- Kramm CM, Wagner S, Van Gool S, et al; Improved survival after gross total resection of malignant gliomas in pediatric patients from the HIT-GBM studies. Anticancer Res. 2006 Sep-Oct;26(5B):3773-9.
- Abla O, Weitzman S; Primary central nervous system lymphoma in children. Neurosurg Focus. 2006 Nov 15;21(5):E8.
- Lee MJ, Ra YS, Park JB, et al; Effectiveness of novel combination chemotherapy, consisting of 5-fluorouracil, vincristine, cyclophosphamide and etoposide, in the treatment of low-grade gliomas in children. J Neurooncol. 2006 Dec;80(3):277-84. Epub 2006 Jun 29.
- Kiehna EN, Mulhern RK, Li C, et al; Changes in attentional performance of children and young adults with localized primary brain tumors after conformal radiation therapy. J Clin Oncol. 2006 Nov 20;24(33):5283-90.
- Nathan PC, Patel SK, Dilley K, et al; Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer: a report from the Children's Oncology Group. Arch Pediatr Adolesc Med. 2007 Aug;161(8):798-806.
- Neglia JP, Robison LL, Stovall M, et al; New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2006 Nov 1;98(21):1528-37.
- Martinez-Lage J, Ros de San Pedro J, Martinez-Perez M, et al; Meningiomas after radiation-therapy for benign astrocytomas. Neurocirugia (Astur). 2005 Jun;16(3):266-70; discussion 270.
- Pietila S, Sievanen H, Ala-Houhala M, et al; Bone mineral density is reduced in brain tumour patients treated in childhood. Acta Paediatr. 2006 Oct;95(10):1291-7.
- Jain R, Robertson PL, Gandhi D, et al; Radiation-induced cavernomas of the brain. AJNR Am J Neuroradiol. 2005 May;26(5):1158-62.
- Goh YI, Bollano E, Einarson TR, et al; Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clin Pharmacol Ther. 2007 May;81(5):685-91. Epub 2007 Feb 21.
|Original Author: Dr Gurvinder Rull||Current Version: Dr Colin Tidy|
|Last Checked: 22/06/2011||Document ID: 1883 Version: 23||© EMIS|
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